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Updated: Jan 25, 2026
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A Randomized Controlled Study of Integrated Smoking Cessation in a Lung Cancer Screening Program
Alain Tremblay1, Niloofar Taghizadeh1, Jane Huang2
1Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Summary
Intensive telephone counseling did not improve smoking cessation rates in lung cancer screening participants. This suggests routine referral to cessation programs may not be effective for this group.
Area of Science:
- Oncology
- Public Health
- Behavioral Science
Background:
- Smoking cessation is recommended for lung cancer screening programs.
- Previous studies have not demonstrated increased quit rates with cessation programs in this setting.
Purpose of the Study:
- To evaluate the effectiveness of telephone-based smoking cessation counseling for smokers undergoing lung cancer screening.
Main Methods:
- A randomized controlled trial compared intensive telephone counseling with usual care (pamphlet).
- 345 active smokers in the Alberta Lung Cancer Screening Study were randomized.
- The primary endpoint was self-reported 30-day smoking abstinence at 12 months.
Main Results:
- Smoking abstinence at 12 months was 12.6% in the control group and 14.0% in the intervention group (1.4% difference, p=0.7).
- No statistically significant differences were observed in 7-day or point abstinence, or at 6 or 24 months.
Conclusions:
- Telephone-based smoking cessation counseling did not increase 12-month cessation rates compared to usual care in unselected lung cancer screening participants.
- Routine referral to counseling may not improve long-term cessation in this cohort.
- Future research should focus on older, long-term smokers to optimize integrated cessation strategies.
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