Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genetics of Speciation02:16

Genetics of Speciation

21.0K
Speciation is the evolutionary process resulting in the formation of new, distinct species—groups of reproductively isolated populations.
21.0K
Binet's Contribution to Measures of Intelligence01:23

Binet's Contribution to Measures of Intelligence

1.7K
Alfred Binet, along with his student Théophile Simon, was tasked by the French Ministry of Education in 1904 to create a method for identifying students who struggled to learn through conventional classroom instruction. This initiative aimed to address overcrowding by placing such students in specialized schools. Binet and Simon developed an intelligence test comprising 30 tasks, ranging from simple commands, like touching one's nose or ear, to more complex tasks, such as drawing...
1.7K
Relative Risk01:12

Relative Risk

2.0K
Relative risk (RR) is a statistical measure commonly used in epidemiology to compare the likelihood of a particular event occurring between two groups. This metric is important for evaluating the relationship between exposure to a specific risk factor and the probability of a particular outcome. It plays a crucial role in medical research, public health studies, and risk assessment. Relative risk quantifies how much more (or less) likely an event is to occur in an exposed group compared to an...
2.0K
Wechsler's Contribution to Measures of Intelligence01:23

Wechsler's Contribution to Measures of Intelligence

2.1K
David Wechsler, a psychologist who worked with World War I veterans, developed a significant IQ test in 1939 called the Wechsler-Bellevue Intelligence Scale. This test was innovative because it combined several subtests that measured both verbal and nonverbal skills, reflecting Wechsler's belief that intelligence is a global capacity involving purposeful action, rational thinking, and effective interaction with the environment. This test later evolved into the Wechsler Adult Intelligence...
2.1K
Mutation, Gene Flow, and Genetic Drift01:09

Mutation, Gene Flow, and Genetic Drift

63.4K
In a population that is not at Hardy-Weinberg equilibrium, the frequency of alleles changes over time. Therefore, any deviations from the five conditions of Hardy-Weinberg equilibrium can alter the genetic variation of a given population. Conditions that change the genetic variability of a population include mutations, natural selection, non-random mating, gene flow, and genetic drift (small population size).
63.4K
What is Population Genetics?01:25

What is Population Genetics?

64.5K
A population is composed of members of the same species that simultaneously live and interact in the same area. When individuals in a population breed, they pass down their genes to their offspring. Many of these genes are polymorphic, meaning that they occur in multiple variants. Such variations of a gene are referred to as alleles. The collective set of all the alleles within a population is known as the gene pool.
64.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Exploring glucocorticoid receptor signalling in lymphangioleiomyomatosis.

ERJ open research·2026
Same author

Die Anaesthesiologie·2026
Same author

[Advantages of a standardized PONV prophylaxis : The consistent implementation significantly reduces the incidence of postoperative nausea and vomiting and the need for antiemetic rescue medication].

Die Anaesthesiologie·2026
Same author

Systemic downregulation of EV-associated MiRNAs following remote ischemic preconditioning.

Scientific reports·2025
Same author

Farnesyltransferase inhibitors decrease matrix-vesicle-mediated mineralization in SaOS-2 cells.

Molecular biology reports·2025
Same author

Preoperative cognitive impairment predicts deep anaesthesia and higher postoperative pain in elderly patients: an observational study.

BMC anesthesiology·2025

Related Experiment Video

Updated: Jan 25, 2026

Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
09:38

Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease

Published on: November 14, 2017

15.6K

Genetic contribution to PONV risk.

Stefanie Klenke1, Gudrun J de Vries1, Laura Schiefer1

  • 1Klinik für Anästhesiologie and Intensivmedizin, University of Duisburg-Essen and Universitätsklinikum Essen, Hufelandstr. 55, D-45122 Essen, Germany.

Anaesthesia, Critical Care & Pain Medicine
|May 12, 2019
PubMed
Summary

Genetic factors influence postoperative nausea and vomiting (PONV) risk. The KCNB2 rs349358 single nucleotide polymorphism (SNP) and a combined genetic risk score are significant predictors of PONV, independent of the Apfel Score.

Keywords:
Apfel scoreGenetic predispositionKCNB2PONVrs2165870rs349358

More Related Videos

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
19:15

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Published on: August 25, 2014

87.6K
An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations
10:17

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations

Published on: November 3, 2010

23.3K

Related Experiment Videos

Last Updated: Jan 25, 2026

Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
09:38

Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease

Published on: November 14, 2017

15.6K
Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
19:15

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Published on: August 25, 2014

87.6K
An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations
10:17

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations

Published on: November 3, 2010

23.3K

Area of Science:

  • Pharmacogenomics
  • Clinical Genetics
  • Anesthesiology

Background:

  • Postoperative nausea and vomiting (PONV) is a common complication.
  • Clinical risk stratification for PONV typically uses the Apfel Score.
  • Genetic predisposition to PONV is suggested, with CHRM3 rs2165870 SNP identified previously.

Purpose of the Study:

  • To investigate additional single nucleotide polymorphisms (SNPs) contributing to PONV risk.
  • To develop and evaluate a genetic risk score for summarizing genetic PONV risk.

Main Methods:

  • Retrospective analysis of 472 patients undergoing elective surgery.
  • Investigation of specific SNPs including rs3218315 (IL2RB), rs349358 (KCNB2), rs703363, rs1800497 (DRD2), rs1799971 (OPRM1), and rs1176713 (HTR3A).
  • Creation and association analysis of a genetic risk score with PONV incidence.

Main Results:

  • Early PONV occurred in 37% of patients.
  • The KCNB2 rs349358 SNP showed significant association with nausea, retching, and PONV (P < 0.05).
  • A genetic risk score combining CHRM3 rs2165870 and KCNB2 rs349358 was independently associated with PONV risk (P < 0.0001).

Conclusions:

  • The KCNB2 rs349358 SNP is an independent predictor of PONV.
  • A developed genetic risk score demonstrates a significant impact on PONV susceptibility, comparable to the Apfel Score.