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The microbiome: toward preventing allergies and asthma by nutritional intervention
Olaf Perdijk1, Benjamin J Marsland1
1Department of Immunology and Pathology, Central Clinical School, Monash University, Melbourne, VIC 3004, Australia.
Current Opinion in Immunology
|May 12, 2019
Summary
Rising allergies and asthma highlight the need for new therapies. Understanding nutrition-microbe-host interactions is key to developing effective dietary strategies for preventing and treating allergic diseases.
Area of Science:
- Immunology
- Microbiome research
- Nutritional science
Background:
- Allergies and asthma prevalence has increased significantly in recent decades.
- Therapeutic development for these conditions has stagnated.
- Host-environment-microbe interactions, influenced by genetics and lifestyle, are critical in disease susceptibility.
Purpose of the Study:
- To investigate the role of the microbiome in allergic diseases.
- To explore nutritional intervention strategies for modulating the microbiome.
- To understand the mechanisms of nutrition-microbe-host interactions in allergy and asthma.
Main Methods:
- Review of current literature on microbiome, nutrition, and allergic diseases.
- Analysis of host-environment-microbe interactions.
- Exploration of trans-kingdom interactions in disease pathogenesis.
Main Results:
- Nutritional interventions show promise for shaping a health-promoting microbiome.
- Mechanistic insights into the nutrition-microbe-host interplay are currently lacking.
- The influence of trans-kingdom interactions on disease susceptibility requires further investigation.
Conclusions:
- Understanding host-microbe interactions is crucial for developing effective dietary interventions.
- Targeting the microbiome through nutrition may offer new therapeutic avenues for allergies and asthma.
- Further research into the mechanisms underlying these interactions is essential for clinical application.
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