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The functions and oncogenic roles of CCAT1 in human cancer

Zheng Liu1, QianJun Chen2, Swei Sunny Hann3

  • 1Laboratory of Tumor Biology, The Second Clinical Collage of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, 510120, China.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|May 12, 2019
PubMed

Insights

Long non-coding RNAs (lncRNAs) regulate cancer. Colon cancer-associated transcript 1 (CCAT1) is a key lncRNA involved in tumor growth and progression, offering potential as a cancer biomarker and therapeutic target.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Long non-coding RNAs (lncRNAs) are crucial regulators of gene expression involved in various biological processes.
  • Aberrant expression of lncRNAs, including CCAT1, is linked to cancer development and progression.
  • The precise mechanisms of lncRNA action in cancer remain under investigation.

Purpose of the Study:

  • To review the concept, identification, and biological functions of CCAT1.
  • To elucidate the regulatory mechanisms of CCAT1 in cancer proliferation and progression.
  • To discuss the potential of CCAT1 as a biomarker and therapeutic target in oncology.

Main Methods:

  • Literature review of studies on CCAT1 in human cancers.
  • Analysis of CCAT1's role in gene expression regulation at multiple levels.
  • Synthesis of current understanding of CCAT1's involvement in oncogenesis and metastasis.

Main Results:

  • CCAT1 is highly expressed and plays an oncogenic role in various human cancers.
  • CCAT1 influences tumor-genesis, progression, metastasis, and patient survival.
  • CCAT1 regulates cancer development by targeting specific genes and signaling pathways.

Conclusions:

  • CCAT1 is a significant lncRNA with a well-defined role in cancer.
  • Understanding CCAT1's mechanisms provides insights into cancer biology.
  • CCAT1 holds promise as a diagnostic biomarker and therapeutic target for novel cancer treatments.
Keywords:
BiomarkersCCAT1CancersLong non-coding RNATherapeutic targets

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