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Jeffrey Arnett's concept of emerging adulthood offers a framework to understand the unique developmental stage between adolescence and full-fledged adulthood, generally from ages 18 to 25. This period is marked by extensive exploration and shifts in identity, relationships, and career choices, a process known in psychology as role experimentation. Emerging adulthood reflects the evolving cultural expectations surrounding adulthood and the dynamic process of personal transformation during...
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Exosomes: An emerging factor in atherosclerosis.

Yanan Wang1, Yingyu Xie1, Ao Zhang2

  • 1First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, 314 An Shan Xi Road, Nan Kai District, Tianjin, 300193, China; Tianjin University of Traditional Chinese Medicine, 312 An Shan Xi Road, Nan Kai District, Tianjin, 300193, China.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|May 12, 2019
PubMed
Summary
This summary is machine-generated.

Exosomes, tiny vesicles involved in cell communication, are key players in atherosclerosis, a major cause of cardiovascular disease. Research highlights their potential as biomarkers for diagnosing and treating this condition.

Keywords:
AtherosclerosisEndothelial cellExosomeExtracellular vesiclesMicroRNAPlateletVascular smooth muscle cell

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Area of Science:

  • Cardiovascular Biology
  • Cellular and Molecular Medicine
  • Biomarker Discovery

Background:

  • Atherosclerosis is a leading cause of global mortality, accounting for approximately 20% of all deaths.
  • Exosomes are extracellular vesicles crucial for intercellular communication, influencing physiological and pathological processes.
  • The role of exosomes in cardiovascular diseases, particularly atherosclerosis, is gaining significant research attention.

Purpose of the Study:

  • To review the roles of exosomes and their components (microRNAs, proteins, DNA) as biomarkers in atherosclerosis development.
  • To explore the mechanisms of exosome-mediated intercellular communication in atherosclerosis.
  • To identify potential diagnostic and therapeutic applications of exosomes in atherosclerosis.

Main Methods:

  • Literature review of current research on exosomes and atherosclerosis.
  • Analysis of studies investigating exosome-derived molecules (miRNAs, proteins, DNA) as biomarkers.
  • Examination of mechanisms underlying exosome-mediated intercellular crosstalk in the context of atherosclerosis.

Main Results:

  • Exosomes and their cargo (miRNAs, proteins, DNA) serve as significant biomarkers in atherosclerosis.
  • Exosome-mediated intercellular communication is integral to the pathogenesis of atherosclerosis.
  • Evidence suggests exosomes have potential roles in both the diagnosis and treatment of atherosclerosis.

Conclusions:

  • Exosomes represent a promising avenue for biomarker development in atherosclerosis.
  • Understanding exosome-mediated crosstalk is crucial for elucidating atherosclerosis mechanisms.
  • Exosomes offer potential for novel diagnostic and therapeutic strategies against atherosclerosis.