Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hormones and multistage carcinogenesis.

S H Moolgavkar

    Cancer Surveys
    |January 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Hormones influence cancer development by affecting initiated cells. This study uses a two-stage model to explain hormone roles in carcinogenesis, particularly in breast and endometrial cancers.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Systems biological and mechanistic modelling of radiation-induced cancer.

    Radiation and environmental biophysics·2007
    Same author

    Consideration of copollutants.

    Science (New York, N.Y.)·2007
    Same author

    A generalized Luria-Delbrück model.

    Mathematical biosciences·2005
    Same author

    From mechanisms to risk estimation--bridging the chasm.

    Advances in space research : the official journal of the Committee on Space Research (COSPAR)·2005
    Same author

    The use of biologically based cancer risk models in radiation epidemiology.

    Radiation protection dosimetry·2003
    Same author

    Air pollution and hospital admissions for chronic obstructive pulmonary disease in three metropolitan areas in the United States.

    Inhalation toxicology·2003
    Same journal

    Future directions: bladder cancer.

    Cancer surveys·2004
    Same journal

    Radiotherapy and chemotherapy for invasive bladder cancer.

    Cancer surveys·2004
    Same journal

    The role of surgery in the multimodality treatment of bladder cancer.

    Cancer surveys·2004
    Same journal

    Clonal development of bladder cancer and its relevance to the clinical potential of HLA antigen and TP53 based gene therapy.

    Cancer surveys·2004
    Same journal

    Clinical evaluation of immunotherapy: are there differences between papillary and flat in situ bladder cancer?

    Cancer surveys·2004
    Same journal

    Molecular biological changes in bladder cancer.

    Cancer surveys·2004
    See all related articles

    Area of Science:

    • Oncology
    • Endocrinology
    • Epidemiology

    Background:

    • Carcinogenesis involves initiation and promotion stages.
    • Hormones are implicated in various cancer types.
    • A two-stage model of malignant transformation is widely accepted.

    Purpose of the Study:

    • To analyze the role of hormones in carcinogenesis.
    • To frame hormone influence within a two-stage malignant transformation model.
    • To discuss hormone roles in breast and endometrial cancers.

    Main Methods:

    • Utilizing the Moolgavkar and Knudson two-stage carcinogenesis model.
    • Reviewing epidemiological and experimental data.
    • Analyzing hormonal influences on cell populations.

    Related Experiment Videos

    Main Results:

    • The two-stage model aligns with existing carcinogenesis data.
    • Hormones primarily affect carcinogenesis through clonal expansion or contraction of initiated cells.
    • Hormonal mechanisms in breast and endometrial cancer were examined.

    Conclusions:

    • Hormonal influence on carcinogenesis is best explained by effects on initiated cell populations.
    • The two-stage model provides a robust framework for understanding hormone-driven cancers.
    • Further research into specific hormonal pathways in cancer is warranted.