Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mitral Valve Prolapse I: Introduction01:27

Mitral Valve Prolapse I: Introduction

437
IntroductionThe mitral valve, one of the heart's four valves, regulates blood flow. These valves have flaps that open and close to direct blood properly through the heart and body. During each heartbeat, the flaps open for blood to pass through and seal shut to prevent backflow. Specifically, the mitral valve opens to allow blood flow from the heart's upper left chamber to the lower left chamber. It then closes securely as the lower left chamber contracts to pump blood to the body, preventing...
437
Mitral Valve Prolapse II: Assessment and Management01:22

Mitral Valve Prolapse II: Assessment and Management

501
IntroductionA range of clinical features characterizes Mitral Valve Prolapse (MVP), but it is important to note that many individuals with MVP are asymptomatic and may remain so throughout their lives. For those who do exhibit symptoms, the following are the key clinical features:Palpitations: This is a common symptom where individuals feel an irregular or rapid heartbeat. Palpitations in MVP are often due to arrhythmias such as premature ventricular contractions or supraventricular...
501
Mitral Valve Prolapse III: Nursing Management01:19

Mitral Valve Prolapse III: Nursing Management

330
The nursing management of Mitral Valve Prolapse, or MVP, centers around patient education, symptom monitoring, and lifestyle modifications.Patient Education on MVP Diagnosis and Heredity: Nurses should provide comprehensive education about MVP, a condition where the mitral valve does not close appropriately during heartbeats. This education often includes the condition's pathophysiology, symptoms, and potential complications, like arrhythmias or mitral regurgitation. Though not fully...
330
Heart Valves01:16

Heart Valves

11.4K
The human heart is a complex organ with an intricate system of valves that regulate blood flow. There are two main types of valves: atrioventricular (AV) valves and semilunar valves.
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
11.4K
Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

471
Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
471
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

548
Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
548

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of Adverse Events on Costs and Length of Stay Following Transcatheter Tricuspid Valve Replacement.

Structural heart : the journal of the Heart Team·2026
Same author

Left and Right Heart Remodelling at 1 Year After Transcatheter Versus Surgical Aortic Valve Replacement: A Speckle-Tracking Echocardiography Study.

Interdisciplinary cardiovascular and thoracic surgery·2026
Same author

Age and Procedural Timing for Asymptomatic Severe Aortic Stenosis: Analysis From the EARLY TAVR Trial.

Circulation. Cardiovascular interventions·2026
Same author

Impact of Residual Mitral Regurgitation and Gradient After M‑TEER: 1‑Year Outcomes From the CLASP IID Trial.

JACC. Cardiovascular imaging·2026
Same author

Transcatheter Annuloplasty Using the Cardioband System: Insights From a European Multicenter Registry (TITAN Registry).

JACC. Cardiovascular interventions·2026
Same author

One-Year Outcomes of Screen Failures for Transcatheter Tricuspid Valve Repair: Insights From the TriSelect Study.

Circulation. Cardiovascular interventions·2026

Related Experiment Video

Updated: Jan 25, 2026

Four-Dimensional Computed Tomography-Guided Valve Sizing for Transcatheter Pulmonary Valve Replacement
09:57

Four-Dimensional Computed Tomography-Guided Valve Sizing for Transcatheter Pulmonary Valve Replacement

Published on: January 20, 2022

3.1K

Transcatheter Mitral Valve Replacement with Intrepid.

Patrick M McCarthy1, Olga N Kislitsina2, Sukit Chris Malaisrie3

  • 1Division of Cardiac Surgery, Northwestern University Feinberg School of Medicine, Northwestern University, 201 East Huron Street, Suite 11-140, Chicago, IL 60611-2908, USA.

Interventional Cardiology Clinics
|May 13, 2019
PubMed
Summary
This summary is machine-generated.

Transcatheter mitral valve replacement using the Intrepid device offers a new option for high-risk patients. Early trials and device details are reviewed, highlighting unique challenges in mitral valve interventions.

Keywords:
Apollo trialMitral regurgitationMitral valveTranscatheter mitral valve replacement

More Related Videos

Transcatheter Pulmonary Valve Replacement from Autologous Pericardium with a Self-Expandable Nitinol Stent in an Adult Sheep Model
05:31

Transcatheter Pulmonary Valve Replacement from Autologous Pericardium with a Self-Expandable Nitinol Stent in an Adult Sheep Model

Published on: June 8, 2022

3.4K
Author Spotlight: Revolutionizing Remote Surgery with Augmented Reality and Robotics for Enhanced Precision and Accessibility
07:46

Author Spotlight: Revolutionizing Remote Surgery with Augmented Reality and Robotics for Enhanced Precision and Accessibility

Published on: August 9, 2024

1.2K

Related Experiment Videos

Last Updated: Jan 25, 2026

Four-Dimensional Computed Tomography-Guided Valve Sizing for Transcatheter Pulmonary Valve Replacement
09:57

Four-Dimensional Computed Tomography-Guided Valve Sizing for Transcatheter Pulmonary Valve Replacement

Published on: January 20, 2022

3.1K
Transcatheter Pulmonary Valve Replacement from Autologous Pericardium with a Self-Expandable Nitinol Stent in an Adult Sheep Model
05:31

Transcatheter Pulmonary Valve Replacement from Autologous Pericardium with a Self-Expandable Nitinol Stent in an Adult Sheep Model

Published on: June 8, 2022

3.4K
Author Spotlight: Revolutionizing Remote Surgery with Augmented Reality and Robotics for Enhanced Precision and Accessibility
07:46

Author Spotlight: Revolutionizing Remote Surgery with Augmented Reality and Robotics for Enhanced Precision and Accessibility

Published on: August 9, 2024

1.2K

Area of Science:

  • Cardiovascular Medicine
  • Interventional Cardiology
  • Medical Device Technology

Background:

  • Transcatheter mitral valve replacement (TMVR) is an emerging alternative for patients with severe mitral valve disease who are poor candidates for traditional open-heart surgery.
  • The Intrepid device represents a novel transcatheter solution designed to address the complexities of mitral valve anatomy and function.

Purpose of the Study:

  • To review the early feasibility and randomized trial data for the Intrepid transcatheter mitral valve replacement system.
  • To discuss the device design, implantation procedure, and the unique physiological challenges associated with transcatheter mitral valve interventions.

Main Methods:

  • Review of published results from the early feasibility trial of the Intrepid device.
  • Analysis of the design and implantation technique for the Intrepid TMVR system.
  • Examination of the Apollo trial, comparing the Intrepid device to conventional surgery and including a cohort of inoperable patients.

Main Results:

  • Early feasibility data provides initial insights into the safety and efficacy of the Intrepid device.
  • The Apollo trial is evaluating the performance of the Intrepid device against standard surgical approaches.
  • Unique anatomical and physiological factors of the mitral valve present specific challenges for transcatheter implantation.

Conclusions:

  • The Intrepid device shows promise as a transcatheter option for mitral valve replacement in high-risk surgical patients.
  • Understanding and overcoming the specific hurdles of mitral valve structure and physiology is crucial for successful transcatheter implantation.
  • Further data from trials like Apollo will define the role of the Intrepid system in managing mitral valve disease.