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Related Concept Videos

CRISPR and crRNAs02:53

CRISPR and crRNAs

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Bacteria and archaea are susceptible to viral infections just like eukaryotes; therefore, they have developed a unique adaptive immune system to protect themselves. Clustered regularly interspaced short palindromic repeats and CRISPR-associated proteins (CRISPR-Cas) are present in more than 45% of known bacteria and 90% of known archaea.
The CRISPR-Cas system stores a copy of foreign DNA in the host genome and uses it to identify the foreign DNA upon reinfection. CRISPR-Cas has three different...
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CRISPR01:59

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Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced...
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Power01:08

Power

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The concept of work involves force and displacement; meanwhile, the work-energy theorem relates the net work done on a body to the difference in its kinetic energy, calculated between two points on its trajectory. While none of these quantities or relations involves time explicitly, we know that the time available to accomplish work is often just as important as the amount of work itself. For example, sprinters in a race may have achieved the same velocity at the finish, therefore,...
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Power System Distribution01:25

Power System Distribution

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Power system distribution involves delivering electrical energy from power plants to consumers through a network of transmission and distribution systems. The process begins at power plants, where energy from coal, gas, nuclear, water, and wind is converted into electrical energy. These plants use three-phase generators, typically rated between 50 to 1300 MVA, with terminal voltages ranging from a few kV to 20 kV, depending on the size and age of the units.
The transmission system is designed...
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Nuclear Power02:36

Nuclear Power

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Controlled nuclear fission reactions are used to generate electricity. Any nuclear reactor that produces power via the fission of uranium or plutonium by bombardment with neutrons has six components: nuclear fuel consisting of fissionable material, a nuclear moderator, a neutron source, control rods, reactor coolant, and a shield and containment system.
Nuclear Fuels
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Power and Energy01:12

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The power and energy delivered to an element are subjects of great significance in the field of electrical engineering. It is a well-known fact that a 100-watt light bulb emits more light than a 60-watt one. Therefore, power and energy calculations play a crucial role in the analysis of electrical circuits.
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Related Experiment Video

Updated: Jan 25, 2026

Substrate Generation for Endonucleases of CRISPR/Cas Systems
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Substrate Generation for Endonucleases of CRISPR/Cas Systems

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CRISPR/Cas Powered Multiplexed Biosensing.

Richard Bruch1, Gerald A Urban2, Can Dincer3

  • 1University of Freiburg, Department of Microsystems Engineering (IMTEK), Laboratory for Sensors, 79110 Freiburg, Germany; University of Freiburg, Freiburg Center for Interactive Materials and Bioinspired Technologies (FIT), 79110 Freiburg, Germany.

Trends in Biotechnology
|May 13, 2019
PubMed
Summary

Multiplexed CRISPR/Cas biosensing enables disease diagnosis by detecting multiple analytes. Current challenges limit multiplexing, but strategies exist to advance this powerful diagnostic technology.

Keywords:
CRISPR/Cas systemsmultiplexingnucleic acid diagnosticspoint-of-care testing

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Last Updated: Jan 25, 2026

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Area of Science:

  • Biotechnology
  • Molecular Diagnostics
  • CRISPR/Cas Systems

Background:

  • Multiplexed CRISPR/Cas biosensing allows for simultaneous detection of multiple disease biomarkers from a single sample.
  • This approach holds significant promise for improving diagnostic efficiency and reducing costs.

Discussion:

  • Significant technical hurdles currently impede the development of highly multiplexed CRISPR/Cas biosensing platforms.
  • Key challenges include signal interference, probe design, and efficient detection of numerous analytes.

Key Insights:

  • The limited number of existing multiplexing approaches highlights the nascent stage of this diagnostic technology.
  • Understanding the root causes of these limitations is crucial for future advancements.

Outlook:

  • Developing innovative strategies is essential to overcome current limitations and enhance multiplexing capabilities.
  • Future research should focus on robust assay designs and integrated detection systems to realize the full potential of multiplexed CRISPR/Cas diagnostics.