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Related Experiment Video

Updated: Jan 25, 2026

Induction of Experimental Autoimmune Hypophysitis in SJL Mice
10:38

Induction of Experimental Autoimmune Hypophysitis in SJL Mice

Published on: December 17, 2010

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New causes of hypophysitis.

Kevin C J Yuen1, Vera Popovic2, Peter J Trainer3

  • 1Barrow Pituitary Center, Barrow Neurological Institute, University of Arizona College of Medicine and Creighton School of Medicine, Phoenix, Arizona, United States.

Best Practice & Research. Clinical Endocrinology & Metabolism
|May 13, 2019
PubMed
Summary

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Hypophysitis, a rare pituitary gland inflammation, can cause hormone deficiencies and mass effects. Management involves hormone replacement and glucocorticoids, with surgery reserved for severe cases.

Area of Science:

  • Endocrinology
  • Immunology
  • Neurology

Background:

  • Hypophysitis is a rare inflammation of the pituitary gland and stalk.
  • It can lead to hypopituitarism and/or mass effect.
  • Etiologies include primary causes or secondary to systemic diseases, with new links to immunomodulatory drugs and IgG4-related disease.

Purpose of the Study:

  • To review the etiology, diagnosis, and management of hypophysitis.
  • To highlight recent advancements in understanding hypophysitis.
  • To identify unmet needs in clinical practice.

Main Methods:

  • Review of clinical, laboratory, and imaging data.
  • Consideration of anatomical and histopathological criteria.
  • Assessment of treatment outcomes with hormone replacement, glucocorticoids, and surgery.
Keywords:
IgG4-related diseaseIgG4-related hypophysitisautoimmunehypophysitisimmune checkpoint inhibitoripilimumab

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Related Experiment Videos

Last Updated: Jan 25, 2026

Induction of Experimental Autoimmune Hypophysitis in SJL Mice
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Induction of Experimental Autoimmune Hypophysitis in SJL Mice

Published on: December 17, 2010

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Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis
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Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis

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Main Results:

  • Diagnosis relies on clinical presentation, lab results, and imaging; biopsy is rarely needed.
  • Effective management includes hormone replacement for hypopituitarism and high-dose glucocorticoids for inflammatory mass.
  • Surgery is reserved for refractory or progressive cases.

Conclusions:

  • Hypophysitis requires a comprehensive approach integrating clinical, laboratory, and imaging findings.
  • Current management strategies are effective but require further validation through controlled studies.
  • There is an ongoing need for research to refine treatment protocols for hypophysitis.