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Proteoglycan signaling in tumor angiogenesis and endothelial cell autophagy

Maria A Gubbiotti1, Simone Buraschi1, Aastha Kapoor1

  • 1Department of Pathology, Anatomy, and Cell Biology and the Cancer Cell Biology and Signaling Program, Sidney Kimmel Medical College and Cancer Center, Thomas Jefferson University, Philadelphia, PA, United States.

Seminars in Cancer Biology
|May 13, 2019
PubMed

Insights

Proteoglycan signaling influences cancer progression by affecting angiogenesis and autophagy. Targeting these pathways offers new therapeutic strategies for cancer treatment.

Area of Science:

  • Cancer Biology
  • Molecular Signaling
  • Proteoglycan Biology

Background:

  • Cancer therapies face challenges due to tumor complexity and adaptability.
  • Proteoglycan signaling is an emerging area with potential for novel cancer drug targets.
  • The interplay between extracellular signaling, autophagy, and angiogenesis is a key trend in proteoglycan biology.

Purpose of the Study:

  • To summarize current evidence on proteoglycan signaling in cancer.
  • To highlight the roles of proteoglycans in autophagy and angiogenesis.
  • To identify potential therapeutic strategies based on proteoglycan signaling.

Main Methods:

  • Literature review of current evidence on proteoglycan signaling.
  • Focus on key proteoglycans like decorin and perlecan.
  • Analysis of the link between proteoglycan-mediated signaling, autophagy, and angiogenesis.

Main Results:

  • Proteoglycans play significant roles in regulating extracellular signaling pathways.
  • The interaction between proteoglycans, autophagy, and angiogenesis is crucial for tumor biology.
  • Decorin and perlecan are key proteoglycans involved in these processes.

Conclusions:

  • Proteoglycan signaling offers promising avenues for developing innovative cancer therapies.
  • Understanding the intricate signaling web involving proteoglycans, autophagy, and angiogenesis is vital.
  • Targeting proteoglycans presents a potential strategy to overcome treatment resistance in cancer.
Keywords:
AngiogenesisAutophagyBiglycanDecorinEndostatinPerlecanProteoglycanTumorigenesis

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