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Orientational Transition in a Liquid Crystal Triggered by the Thermodynamic Growth of Interfacial Wetting Sheets
Published on: May 15, 2017
Phase transition and release kinetics of polyphenols encapsulated lyotropic liquid crystals
1College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan 250014, PR China.
Abstract:
In this paper, the lyotropic liquid crystals formed in SL/IP/H2O system were prepared as a drug carrier system to encapsulate polyphenols. The components and introduction of drug had influences in the structure and rheological properties of lyotropic liquid crystals. The structure underwent a phase transition from lamellar phase (Lα) to Lα + HII (reverse hexagonal phase) mixed phases and micelle by increasing its IP/H2O mass ratio from 5/35 to 20/20 and 35/5, consistent with the transition from solid-like properties to viscous fluid properties. For the Lα + HII phase, the loading of DMY induced the structural transition to the HII phase, confirmed by SAXS results. This may be due to the penetration of DMY into the hydrophobic tails of surfactants. The in vitro release kinetic resulted that the release of drug in Lα was associated with diffusional mass transport and matrix swelling. While the release behavior of DMY in HII phase was predominantly controlled by concentration diffusion. These relationships among structure, rheology and release kinetics should be conductive to further design the drug sustained carrier system formed by lyotropic liquid crystals.
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To explain the observed behavior of transition metal complexes (such as colors), a model involving electrostatic interactions between the electrons from the ligands and the electrons in the unhybridized d orbitals of the central metal atom has been developed. This electrostatic model is crystal field theory (CFT). It helps to understand, interpret, and predict the colors, magnetic behavior, and some structures of coordination compounds of transition metals.
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