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Levels of Lipoprotein (a) in patients with coronary artery disease with and without inflammatory rheumatic disease: a

Sverre Holm1,2, Ingvild Oma3,4, Tor-Arne Hagve4,5

  • 1Research Institute of Internal Medicine, Oslo University Hospital, Oslo, Norway.

BMJ Open
|May 13, 2019
PubMed

Insights

Serum Lipoprotein (a) levels did not differ between coronary artery disease patients with and without inflammatory rheumatic diseases. These findings suggest no direct link between inflammation and Lipoprotein (a) in cardiovascular disease patients.

Area of Science:

  • Cardiology
  • Rheumatology
  • Biochemistry

Background:

  • Patients with inflammatory rheumatic diseases (IRDs) face a higher risk of atherothrombotic disease.
  • Lipoprotein (a) (Lp(a)) is a known risk factor for atherosclerosis, but its specific role in IRD patients with coronary artery disease (CAD) remains unclear.

Purpose of the Study:

  • To investigate whether serum Lp(a) levels differ between CAD patients with and without co-existing IRD.
  • To explore the relationship between Lp(a) levels and clinical/biochemical parameters in these patient groups.

Main Methods:

  • A cross-sectional observational cohort study.
  • Serum Lp(a) levels were analyzed using a particle-enhanced immunoturbidimetric assay.
  • Participants included 67 CAD patients with IRD and 52 CAD patients without IRD, all Caucasian and over 18 years old.

Main Results:

  • No significant difference in serum Lp(a) levels was observed between CAD patients with and without IRD.
  • Lp(a) levels showed poor correlation with clinical and biochemical parameters, including C-reactive protein, in both groups.
  • The observed patterns were consistent across both the CAD/IRD and CAD/non-IRD cohorts.

Conclusions:

  • The study data do not support an association between inflammation and Lp(a) levels in patients with CAD.
  • Generally, Lp(a) levels were not found to be correlated with other established cardiovascular disease risk factors in this cohort.
Abstract

Keywords:
atherosclerosiscoronary heart diseaserheumatology

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