Perianal Goblet Cell Carcinoid With Pagetoid Spread

Area of Science:

• Gastroenterology
• Oncology
• Pathology

Background:

• Goblet cell carcinoid (adenocarcinoid tumor) typically originates in the appendix.
• This tumor type contains both neuroendocrine and mucin-containing cells.
• When found outside the appendix, it often indicates metastasis.

Observation:

• An 81-year-old woman presented with a perianal mass.
• Surgical excision and subsequent analysis revealed a goblet cell carcinoid.
• The tumor exhibited pagetoid spread along the perianal squamous mucosa.

Findings:

• Histologic and immunohistochemical examination confirmed the diagnosis.
• No primary appendiceal tumor was identified through history or imaging.
• This represents the first reported case of a perianal goblet cell carcinoid with pagetoid spread.

Implications:

• This case expands the known presentation sites for goblet cell carcinoid.
• Highlights the importance of considering rare presentations in differential diagnoses.
• The patient's metastatic disease led to death 26 months post-diagnosis, underscoring tumor aggressiveness.