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High-Performance Liquid Chromatography: Introduction01:11

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Related Experiment Video

Updated: Jan 25, 2026

Use of MRI-ultrasound Fusion to Achieve Targeted Prostate Biopsy
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Prostate biopsy: when and how to perform.

C J Das1, A Razik1, S Sharma1

  • 1Department of Radiology, All India Institute of Medical Sciences (A.I.I.M.S), Ansari Nagar, New Delhi, 110029, India.

Clinical Radiology
|May 14, 2019
PubMed
Summary
This summary is machine-generated.

Systematic transrectal biopsy missed prostate cancers. Multiparametric MRI-targeted biopsies improve detection of significant prostate cancer but are costly and complex.

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Area of Science:

  • Urology
  • Oncology
  • Radiology

Background:

  • Historically, systematic transrectal ultrasound (TRUS) biopsy protocols for prostate cancer had low sensitivity due to undersampling.
  • This led to missed diagnoses, particularly in anterior, lateral peripheral zones, and the apex.
  • Increasing core numbers improved detection but also raised complication rates and detected more insignificant cancers.

Purpose of the Study:

  • To review the evolution of prostate cancer biopsy techniques.
  • To compare systematic TRUS biopsy with MRI-targeted biopsy methods.
  • To outline indications, workflow, and outcomes of these procedures.

Main Methods:

  • Review of historical systematic transrectal ultrasound (TRUS) biopsy protocols.
  • Introduction and evaluation of multiparametric magnetic resonance imaging (MRI)-targeted biopsies.
  • Discussion of MRI-TRUS fusion and direct in-gantry guidance techniques.

Main Results:

  • MRI-targeted biopsies significantly increase the detection of clinically significant prostate cancer.
  • These advanced techniques improve positive core rates compared to systematic biopsies.
  • However, MRI-guided methods are associated with higher costs and require specialized expertise.

Conclusions:

  • Multiparametric MRI has revolutionized prostate cancer detection and biopsy targeting.
  • MRI-targeted biopsies offer improved sensitivity for clinically significant disease over traditional methods.
  • Despite advantages, the cost and complexity of MRI-guided biopsies necessitate careful consideration of indications and resources.