Neural circuits involved in parkinsonian motor disturbance studied in monkeys

The outline of neurophysiological studies on a parkinsonian model in monkeys with mesencephalic ventromedial tegmental lesions was presented. By radiologically and physiologically controlled, selective deep-seated lesions, rigidity with or without tremor could be produced separately. From the results obtained mainly by microrecording from various levels of the brain, a neural circuit involved in production of rigidity and tremor has been proposed.