Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Levels of Organization01:09

Levels of Organization

139.3K
Biological organization is the classification of biological structures, ranging from atoms at the bottom of the hierarchy to the Earth's biosphere. Each level of the hierarchy represents an increase in complexity that builds upon the previous level.
Molecules Are Composed of Atoms, and Biomolecules Are Assembled from Molecules:
The most basic levels include atoms, molecules, and biomolecules. Atoms, the smallest unit of ordinary matter, are composed of a nucleus and electrons. Molecules...
139.3K
The Movement of Organelles and Vesicles01:43

The Movement of Organelles and Vesicles

6.2K
In eukaryotic cells,  cytoskeletal filaments such as actin, microtubules, and intermediate filaments form a mesh-like cytoskeletal network. These filaments serve as tracks for transporting cellular cargo. Specialized motor proteins use the chemical energy stored in adenosine triphosphate (ATP) for this transport. During interphase, microtubules are polarized, with the plus-end towards the cell periphery and the minus-end towards the cell center. Two microtubule-associated motor proteins,...
6.2K
Aging01:26

Aging

643
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
643
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

3.4K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.4K
Accessory Organs01:31

Accessory Organs

74.0K
Accessory organs are those that participate in the digestion of food but do not come into direct contact with it like the mouth, stomach, or intestine do. Accessory organs secrete enzymes into the digestive tract to facilitate the breakdown of food.
74.0K
Organic Compounds03:02

Organic Compounds

56.9K
All living things are formed mostly of carbon compounds called organic compounds. The category of organic compounds includes both natural and synthetic compounds that contain carbon. Although a single, precise definition has yet to be identified by the chemistry community, most agree that a defining trait of organic molecules is the presence of carbon as the principal element, bonded to hydrogen and other carbon atoms. However, some carbon-containing compounds such as carbonates, cyanides, and...
56.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cytarabine-induced TNFα promotes the expansion and suppressive functions of myeloid-derived suppressor cells in acute myeloid leukaemia.

Scandinavian journal of immunology·2022
Same author

Lamp1 mediates lipid transport, but is dispensable for autophagy in <i>Drosophila</i>.

Autophagy·2022
Same author

Peptidic microarchitecture-trapped tumor vaccine combined with immune checkpoint inhibitor or PI3Kγ inhibitor can enhance immunogenicity and eradicate tumors.

Journal for immunotherapy of cancer·2022
Same author

Peroxisomal Stress Response and Inter-Organelle Communication in Cellular Homeostasis and Aging.

Antioxidants (Basel, Switzerland)·2022
Same author

Case Report: A New Subtype of Lynch Syndrome Associated With <i>MSH2</i> c.1024_1026 Identified in a Chinese Family.

Frontiers in medicine·2022
Same author

Non-targeted analysis of unknown volatile components in scented stationery via headspace GC-Orbitrap MS.

Talanta·2022

Related Experiment Video

Updated: Jan 25, 2026

Frailty Assessment in an Aging Mouse Model
06:58

Frailty Assessment in an Aging Mouse Model

Published on: September 23, 2025

501

Organelle aging: Lessons from model organisms.

Mark Bouska1, Kerui Huang1, Ping Kang1

  • 1Department of Genetics, Development, and Cell Biology, Iowa State University, Ames, IA, 50011, USA.

Journal of Genetics and Genomics = Yi Chuan Xue Bao
|May 14, 2019
PubMed
Summary

Organelle dysfunction drives aging by disrupting cellular balance. This review explores age-related changes in organelles and their mechanisms, focusing on fruit flies, to understand organismal aging.

Keywords:
AutophagosomeCell membraneLongevityLysosomeMitochondriaNucleusProteasome

More Related Videos

Modeling Age-Associated Neurodegenerative Diseases in Caenorhabditis elegans
07:04

Modeling Age-Associated Neurodegenerative Diseases in Caenorhabditis elegans

Published on: August 15, 2020

5.8K
Method of Isolated Ex Vivo Lung Perfusion in a Rat Model: Lessons Learned from Developing a Rat EVLP Program
08:59

Method of Isolated Ex Vivo Lung Perfusion in a Rat Model: Lessons Learned from Developing a Rat EVLP Program

Published on: February 25, 2015

28.5K

Related Experiment Videos

Last Updated: Jan 25, 2026

Frailty Assessment in an Aging Mouse Model
06:58

Frailty Assessment in an Aging Mouse Model

Published on: September 23, 2025

501
Modeling Age-Associated Neurodegenerative Diseases in Caenorhabditis elegans
07:04

Modeling Age-Associated Neurodegenerative Diseases in Caenorhabditis elegans

Published on: August 15, 2020

5.8K
Method of Isolated Ex Vivo Lung Perfusion in a Rat Model: Lessons Learned from Developing a Rat EVLP Program
08:59

Method of Isolated Ex Vivo Lung Perfusion in a Rat Model: Lessons Learned from Developing a Rat EVLP Program

Published on: February 25, 2015

28.5K

Area of Science:

  • Cellular Biology
  • Aging Research
  • Organelle Biology

Background:

  • Cellular processes fail with age, impacting tissue function.
  • Organelle structural and functional changes are key contributors to aging.
  • Organelles are emerging as critical regulators of cellular homeostasis.

Purpose of the Study:

  • To review age-dependent alterations in well-studied organelles.
  • To summarize mechanisms governing organelle aging.
  • To highlight insights from model organisms, particularly Drosophila melanogaster.

Main Methods:

  • Literature review of organelle aging research.
  • Analysis of structural and functional changes during aging.
  • Focus on mechanisms in model organisms.

Main Results:

  • Organelle dysfunction is a significant factor in cellular aging.
  • Specific age-related changes identified in key organelles.
  • Mechanisms of organelle aging are conserved across model organisms.

Conclusions:

  • Understanding organelle aging is crucial for organismal aging insights.
  • Organelle regulation is central to cellular homeostasis and longevity.
  • Drosophila melanogaster serves as a valuable model for studying organelle aging.