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Flecainide--an intravenous infusion regimen.
European Journal of Clinical Pharmacology
|January 1, 1987
Summary
This study shows that an intravenous flecainide infusion regimen quickly achieves and maintains therapeutic drug levels for 48 hours. The treatment was generally effective and well-tolerated in patients.
Area of Science:
- Pharmacology
- Clinical Pharmacy
- Cardiology
Background:
- Flecainide is an antiarrhythmic drug.
- Intravenous administration allows for rapid achievement of therapeutic drug levels.
- Optimizing infusion regimens is crucial for effective and safe drug delivery.
Purpose of the Study:
- To evaluate an intravenous infusion regimen for flecainide.
- To assess the rapid establishment and maintenance of therapeutic flecainide drug levels.
- To determine the efficacy and tolerability of the flecainide infusion regimen.
Main Methods:
- A study involving 12 patients receiving an intravenous flecainide infusion.
- Monitoring of drug levels throughout the 48-hour infusion period.
- Assessment of patient response and adverse events.
Main Results:
- Therapeutic flecainide drug levels were rapidly established.
- Drug levels were maintained effectively throughout the 48-hour infusion.
- The regimen was generally effective and well-tolerated.
Conclusions:
- The studied intravenous flecainide infusion regimen is effective.
- The regimen allows for rapid and sustained therapeutic drug levels.
- Flecainide infusion appears to be a well-tolerated treatment option.