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YAP, but Not RSPO-LGR4/5, Signaling in Biliary Epithelial Cells Promotes a Ductular Reaction in Response to Liver

Lara Planas-Paz1, Tianliang Sun1, Monika Pikiolek1

  • 1Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland.

Cell Stem Cell
|May 14, 2019
PubMed
Summary

Biliary epithelial cells (BECs) are not reliant on WNT/β-catenin signaling for liver regeneration. YAP and mTORC1 pathways are crucial for ductular reaction (DR), while AXIN2 and LGR5 upregulation aids hepatocyte regeneration.

Keywords:
CRISPR screenLGR5YAPductular reactionhepatic progenitor cellliver organoidsliver stem cellsoval cellregenerationsingle-cell RNA sequencing

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