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Updated: Jan 25, 2026

Multimodality Diagnosis of Mesenteric Ischemia
Published on: July 21, 2023
Clinical management of chronic mesenteric ischemia
Louisa Jd van Dijk1,2, Desirée van Noord1,3, Annemarie C de Vries1
1Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Insights
Chronic mesenteric ischemia (CMI) is a condition of reduced blood flow to the gastrointestinal tract. Early diagnosis and multidisciplinary consensus are key for effective treatment, preferably endovascular revascularization.
Area of Science:
- Vascular Surgery
- Gastroenterology
- Radiology
Background:
- Chronic mesenteric ischemia (CMI) results from inadequate blood supply to the gastrointestinal tract, typically due to atherosclerotic stenosis of mesenteric arteries.
- Classic symptoms include postprandial abdominal pain and weight loss, but atypical presentations like discomfort, nausea, vomiting, diarrhea, or constipation can occur.
Purpose of the Study:
- To provide an overview of the clinical management of chronic mesenteric ischemia (CMI).
- To emphasize the importance of early diagnosis and multidisciplinary consensus for optimal patient selection and treatment.
Main Methods:
- Review of clinical management strategies for CMI.
- Diagnosis relies on a triad of clinical symptoms, radiological evaluation of mesenteric vasculature, and functional assessment of mucosal ischemia.
- Multidisciplinary consensus is crucial for accurate diagnosis and treatment planning.
Main Results:
- Patients with atherosclerotic CMI, whether single-vessel or multi-vessel, are best treated with endovascular revascularization.
- Timely diagnosis and treatment of CMI can improve quality of life and prevent acute-on-chronic events.
Conclusions:
- Effective management of CMI requires a comprehensive approach integrating clinical, radiological, and functional assessments.
- Endovascular revascularization is the preferred treatment for selected patients with atherosclerotic CMI.
Abstract:
This This Dutch Mesenteric Ischemia Study group consists of: Ron Balm, Academic Medical Center, Amsterdam Gert Jan de Borst, University Medical Center Utrecht, Utrecht Juliette T Blauw, Medisch Spectrum Twente, Enschede Marco J Bruno, Erasmus MC University Medical Center, Rotterdam Olaf J Bakker, St Antonius Hospital, Nieuwegein Louisa JD van Dijk, Erasmus MC University Medical Center, Rotterdam Hessel CJL Buscher, Gelre Hospitals, Apeldoorn Bram Fioole, Maasstad Hospital, Rotterdam Robert H Geelkerken, Medisch Spectrum Twente, Enschede Jaap F Hamming, Leiden University Medical Center, Leiden Jihan Harki, Erasmus MC University Medical Center, Rotterdam Daniel AF van den Heuvel, St Antonius Hospital, Nieuwegein Eline S van Hattum, University Medical Center Utrecht, Utrecht Jan Willem Hinnen, Jeroen Bosch Hospital, 's-Hertogenbosch Jeroen J Kolkman, Medisch Spectrum Twente, Enschede Maarten J van der Laan, University Medical Center Groningen, Groningen Kaatje Lenaerts, Maastricht University Medical Center, Maastricht Adriaan Moelker, Erasmus MC University Medical Center, Rotterdam Desirée van Noord, Franciscus Gasthuis & Vlietland, Rotterdam Maikel P Peppelenbosch, Erasmus MC University Medical Center, Rotterdam André S van Petersen, Bernhoven Hospital, Uden Pepijn Rijnja, Medisch Spectrum Twente, Enschede Peter J van der Schaar, St Antonius Hospital, Nieuwegein Luke G Terlouw, Erasmus MC University Medical Center, Rotterdam Hence JM Verhagen, Erasmus MC University Medical Center, Rotterdam Jean Paul PM de Vries, University Medical Center Groningen, Groningen Dammis Vroegindeweij, Maasstad Hospital, Rotterdam review provides an overview on the clinical management of chronic mesenteric ischemia (CMI). CMI is defined as insufficient blood supply to the gastrointestinal tract, most often caused by atherosclerotic stenosis of one or more mesenteric arteries. Patients classically present with postprandial abdominal pain and weight loss. However, patients may present with, atypically, symptoms such as abdominal discomfort, nausea, vomiting, diarrhea or constipation. Early consideration and diagnosis of CMI is important to timely treat, to improve quality of life and to prevent acute-on-chronic mesenteric ischemia. The diagnosis of CMI is based on the triad of clinical symptoms, radiological evaluation of the mesenteric vasculature and if available, functional assessment of mucosal ischemia. Multidisciplinary consensus on the diagnosis of CMI is of paramount importance to adequately select patients for treatment. Patients with a consensus diagnosis of single-vessel or multi-vessel atherosclerotic CMI are preferably treated with endovascular revascularization.
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