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Updated: Jan 25, 2026

Radiotracer Administration for High Temporal Resolution Positron Emission Tomography of the Human Brain: Application to FDG-fPET
Published on: October 22, 2019
Application of advanced brain positron emission tomography-based molecular imaging for a biological framework in
Daniela Perani1,2,3, Leonardo Iaccarino1,2, Andreas H Jacobs4,5
1Vita-Salute San Raffaele University, Milan, Italy.
Introduction:
A rapid transition from a clinical-based classification to a pathology-based classification of neurodegenerative conditions, largely promoted by the increasing availability of imaging biomarkers, is emerging. The Framework for Innovative Multi-tracer molecular Brain Imaging, funded by the EU Joint Program - Neurodegenerative Disease Research 2016 "Working Groups for Harmonisation and Alignment in Brain Imaging Methods for Neurodegeneration," aimed at providing a roadmap for the applications of established and new molecular imaging techniques in dementia.
Methods:
We consider current and future implications of adopting a pathology-based framework for the use and development of positron emission tomography techniques.
Results:
This approach will enhance efforts to understand the multifactorial etiology of Alzheimer's disease and other dementias.
Discussion:
The availability of pathology biomarkers will soon transform clinical and research practice. Crucially, a comprehensive understanding of strengths and caveats of these techniques will promote an informed use to take full advantage of these tools.
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