Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Photoelectric Effect02:26

Photoelectric Effect

39.1K
When light of a particular wavelength strikes a metal surface, electrons are emitted. This is called the photoelectric effect. The minimum frequency of light that can cause such emission of electrons is called the threshold frequency, which is specific to the metal. Light with a frequency lower than the threshold frequency, even if it is of high intensity, cannot initiate the emission of electrons. However, when the frequency is higher than the threshold value, the number of electrons ejected...
39.1K
X-ray Crystallography02:18

X-ray Crystallography

25.9K
The size of the unit cell and the arrangement of atoms in a crystal may be determined from measurements of the diffraction of X-rays by the crystal, termed X-ray crystallography.
Diffraction
Diffraction is the change in the direction of travel experienced by an electromagnetic wave when it encounters a physical barrier whose dimensions are comparable to those of the wavelength of the light. X-rays are electromagnetic radiation with wavelengths about as long as the distance between neighboring...
25.9K
Light Acquisition02:16

Light Acquisition

9.4K
In order to produce glucose, plants need to capture sufficient light energy. Many modern plants have evolved leaves specialized for light acquisition. Leaves can be only millimeters in width or tens of meters wide, depending on the environment. Due to competition for sunlight, evolution has driven the evolution of increasingly larger leaves and taller plants, to avoid shading by their neighbors with contaminant elaboration of root architecture and mechanisms to transport water and nutrients.
9.4K
What is Energy?04:10

What is Energy?

58.6K
The universe is composed of matter in different forms, and all forms of matter contain energy.  The different forms of energy on Earth originate from the Sun — the ultimate energy source. Plants capture light energy from the Sun, and, via the process of photosynthesis, convert it into chemical energy. This stored energy from plants can be harnessed in many ways. For example, eating plant products as food provides energy for our body to function, and burning wood or coal (fossilized...
58.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluation of respiratory syncytial virus (RSV) vaccine eligibility in an outpatient adult infectious diseases clinic.

Antimicrobial stewardship & healthcare epidemiology : ASHE·2026
Same author

2026 Updated good practice recommendations for outpatient parenteral antimicrobial therapy (OPAT) in adults and children in the UK.

JAC-antimicrobial resistance·2026
Same author

Infectious Disease Screening and Vaccinations Guidelines for Patients Initiating Immunosuppression for Dermatologic Conditions: A Multidisciplinary Design and Quality Improvement Initiative.

The Australasian journal of dermatology·2026
Same author

A bundle of the top 10 OPAT publications in 2024.

Antimicrobial stewardship & healthcare epidemiology : ASHE·2026
Same author

The Fate of Oral Meds.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2025
Same author

We Cannot Overcome the Mediocrity of Colistin.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2025

Related Experiment Video

Updated: Jan 25, 2026

Determining the Thermodynamic and Kinetic Association of a DNA Aptamer and Tetracycline Using Isothermal Titration Calorimetry
06:02

Determining the Thermodynamic and Kinetic Association of a DNA Aptamer and Tetracycline Using Isothermal Titration Calorimetry

Published on: August 23, 2022

3.6K

Eravacycline: The Tetracyclines Strike Back.

Maria Heaney1, Monica V Mahoney2, Jason C Gallagher1

  • 1Temple University, Philadelphia, PA, USA.

The Annals of Pharmacotherapy
|May 14, 2019
PubMed
Summary

Eravacycline, a novel tetracycline antibiotic, shows efficacy against multidrug-resistant organisms and complicated intra-abdominal infections (cIAIs). It offers an alternative for patients intolerant to other treatments.

Keywords:
carbapenem-resistant Enterobacteriaceaeeravacyclineextended-spectrum β-lactamasemethicillin-resistant Staphylococcus aureusvancomycin-resistant Enterococcus

More Related Videos

Generation of Stable Human Cell Lines with Tetracycline-inducible Tet-on shRNA or cDNA Expression
09:51

Generation of Stable Human Cell Lines with Tetracycline-inducible Tet-on shRNA or cDNA Expression

Published on: March 5, 2013

36.1K
A Tetracycline-regulated Cell Line Produces High-titer Lentiviral Vectors that Specifically Target Dendritic Cells
16:04

A Tetracycline-regulated Cell Line Produces High-titer Lentiviral Vectors that Specifically Target Dendritic Cells

Published on: June 19, 2013

15.0K

Related Experiment Videos

Last Updated: Jan 25, 2026

Determining the Thermodynamic and Kinetic Association of a DNA Aptamer and Tetracycline Using Isothermal Titration Calorimetry
06:02

Determining the Thermodynamic and Kinetic Association of a DNA Aptamer and Tetracycline Using Isothermal Titration Calorimetry

Published on: August 23, 2022

3.6K
Generation of Stable Human Cell Lines with Tetracycline-inducible Tet-on shRNA or cDNA Expression
09:51

Generation of Stable Human Cell Lines with Tetracycline-inducible Tet-on shRNA or cDNA Expression

Published on: March 5, 2013

36.1K
A Tetracycline-regulated Cell Line Produces High-titer Lentiviral Vectors that Specifically Target Dendritic Cells
16:04

A Tetracycline-regulated Cell Line Produces High-titer Lentiviral Vectors that Specifically Target Dendritic Cells

Published on: June 19, 2013

15.0K

Area of Science:

  • Pharmacology and Infectious Diseases
  • Antibiotic Resistance
  • Clinical Therapeutics

Background:

  • The emergence of multidrug-resistant organisms (MDROs) necessitates new therapeutic options.
  • Tetracycline-class antibiotics, including novel derivatives like eravacycline, are being investigated for their activity against resistant pathogens.

Purpose of the Study:

  • To review the pharmacology, pharmacokinetics, efficacy, safety, and therapeutic role of eravacycline.
  • To assess eravacycline's utility in treating infections caused by MDROs.

Main Methods:

  • A comprehensive literature search was performed using PubMed and internet searches for clinical research.
  • Included studies focused on eravacycline's clinical efficacy, safety, and pharmacokinetics in humans and animals.

Main Results:

  • Eravacycline exhibits in vitro activity against a range of MDROs, including MRSA, VRE, ESBL-producing Enterobacteriaceae, and carbapenem-resistant Enterobacteriaceae.
  • Phase III trials demonstrated eravacycline's efficacy in treating complicated intra-abdominal infections (cIAIs) compared to ertapenem and meropenem.
  • Common adverse events included infusion site reactions, nausea, vomiting, and diarrhea.

Conclusions:

  • Eravacycline is an effective new tetracycline antibiotic for treating cIAIs.
  • Its broad spectrum of activity against MDROs makes it a valuable option, particularly when other antibiotics are contraindicated or ineffective.
  • Further data are needed to establish its role in indications beyond cIAIs.