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Association of C1q/TNF-related protein-1 (CTRP1) serum levels with coronary artery disease

Linhui Shen1, Shuhong Wang1, Yuan Ling1

  • 1Department of Geriatrics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

The Journal of International Medical Research
|May 14, 2019
PubMed

Insights

Serum levels of CTRP1 are significantly higher in coronary artery disease (CAD) patients and correlate with disease severity. This suggests CTRP1 is a potential biomarker for CAD.

Area of Science:

  • Biochemistry
  • Immunology
  • Cardiology

Background:

  • Complement C1q tumor necrosis factor-related proteins (CTRPs) regulate metabolism and immune responses.
  • Inflammation is implicated in the development of coronary artery disease (CAD).

Purpose of the Study:

  • To investigate the association between serum CTRP1 levels and CAD.
  • To evaluate CTRP1 as a potential biomarker for CAD prevalence and severity.

Main Methods:

  • Serum CTRP1 and inflammatory cytokine levels were measured using ELISA in 63 controls and 76 CAD patients.
  • CAD severity was assessed by Gensini score.
  • Logistic regression analysis was performed to determine the association between CTRP1 and CAD.

Main Results:

  • Serum CTRP1 levels were significantly higher in CAD patients compared to controls (17.24 ± 1.07 vs. 9.31 ± 0.56 ng/mL).
  • CTRP1 levels increased with CAD severity and positively correlated with tumor necrosis factor-α and interleukin-6.
  • CTRP1 was significantly associated with CAD prevalence.

Conclusions:

  • Serum CTRP1 levels are closely associated with the prevalence and severity of CAD.
  • CTRP1 may serve as a novel and valuable biomarker for CAD.
Abstract

Keywords:
Complement C1q tumor necrosis factor-related protein 1Gensini scoreadipokinebiomarkercoronary artery diseaseinflammationinflammatory cytokines

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