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Predictors of treatment outcome in patients with paediatric onset multiple sclerosis

Tine Iskov Kopp1, Morten Blinkenberg2, Thor Ameri Chalmer1

  • 1The Danish Multiple Sclerosis Registry, Department of Neurology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark/Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.

Multiple Sclerosis (Houndmills, Basingstoke, England)
|May 14, 2019
PubMed

Insights

Disease-modifying therapies (DMTs) show comparable efficacy in pediatric multiple sclerosis (MS) patients to adults. Earlier DMT initiation in pediatric MS is linked to better outcomes, with disease duration and baseline disability predicting treatment response.

Area of Science:

  • Pediatric Neurology
  • Neuroimmunology
  • Clinical Therapeutics

Background:

  • Disease-modifying therapies (DMTs) are increasingly used in pediatric multiple sclerosis (MS).
  • Most efficacy and safety trials for DMTs have focused on adult populations.
  • Limited data exists on treatment outcomes specific to pediatric MS patients.

Purpose of the Study:

  • To identify predictors of treatment outcomes in pediatric-onset MS patients receiving DMTs.
  • To evaluate factors influencing relapse rates and disability progression in young MS patients.

Main Methods:

  • Prospective cohort study utilizing the Danish Multiple Sclerosis Registry.
  • Inclusion of 137 pediatric MS patients initiating DMT before age 18.
  • Analysis of baseline predictors including disease duration and EDSS using regression models.

Main Results:

  • Female sex and disease duration over two years predicted higher relapse rates.
  • Disease duration and baseline EDSS predicted both disability worsening and improvement.
  • No significant difference in outcomes was observed between early (<13 years) and later (≥13 years) MS onset.

Conclusions:

  • DMT efficacy in pediatric MS is comparable to adult MS.
  • Early initiation of DMT in pediatric MS is associated with a favorable prognosis.
  • Predictors of treatment response in pediatric MS include disease duration and baseline disability.
Abstract

Keywords:
Paediatric onset multiple sclerosisdisease-modifying therapiesobservational studypredictors of treatment outcomesreal-world data

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