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Related Concept Videos

Testing a Claim about Mean: Known Population SD01:11

Testing a Claim about Mean: Known Population SD

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A complete procedure of testing the hypothesis about a population mean is explained here.
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Related Experiment Video

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The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
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Psoriasis treatment patterns: a retrospective claims study.

Sara Higa1,2, Beth Devine1, Vaishali Patel2

  • 1The Comparative Health Outcomes, Policy, and Economics (CHOICE) Institute, University of Washington , Seattle , WA , USA.

Current Medical Research and Opinion
|May 14, 2019
PubMed
Summary

Most psoriasis patients lose treatment persistence within a year, often switching or restarting therapies. Treatment type significantly impacts persistence, with TNF-α inhibitors and apremilast showing better retention than other systemic options.

Keywords:
Observational researchclaims datapsoriasistreatment patterns

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Area of Science:

  • Dermatology
  • Pharmacoeconomics
  • Health Services Research

Background:

  • Psoriasis is a chronic inflammatory skin condition requiring long-term systemic therapy.
  • Understanding treatment patterns, including persistence and subsequent events, is crucial for optimizing patient care and resource allocation.

Purpose of the Study:

  • To characterize treatment patterns for systemic psoriasis therapies.
  • To estimate persistence and describe switching and restarting events among new users of systemic psoriasis medications.

Main Methods:

  • Retrospective cohort study using Truven MarketScan databases (2014-2016).
  • Analysis of persistence, switching, and restarting in new systemic psoriasis medication users.
  • Descriptive statistics, time-to-event analyses, and Cox proportional hazards regression were employed.

Main Results:

  • Over 50% of patients lost persistence by 12 months, irrespective of treatment type.
  • Acitretin and non-TNF biologics had the highest persistence loss (85.2% and 73.8%).
  • TNF-α inhibitors (51.8%) and apremilast (56.4%) demonstrated the lowest persistence loss.
  • Restarting treatment was common (60.2% for orals, 79.9% for biologics).
  • Switches commonly occurred from oral agents to TNF-α inhibitors, and from biologics to apremilast.

Conclusions:

  • A majority of patients initiate and then restart systemic psoriasis treatment within a year.
  • Treatment type significantly influences persistence, with notable differences among systemic agents.
  • Observed switching patterns may reflect formulary design and patient preferences for oral therapies.