Frequency of aspirin non responsiveness in patients of ischemic heart disease
Syed Khizar Abbas Rizvi1, Shahida Mohsin2, Tahir Saeed3
1Department of Pathology, Ch. Pervaiz Elahi Institute of Cardiology, Abdali Road, Multan, Pakistan.
Insights
Aspirin resistance occurs in 11% of ischemic heart disease patients. Diabetes and female gender are linked to aspirin treatment failure, highlighting the need for personalized antiplatelet strategies.
Area of Science:
- Cardiology
- Pharmacology
Background:
- Aspirin is a crucial antiplatelet medication for ischemic heart disease (IHD).
- Recurrent ischemic events despite antiplatelet therapy suggest aspirin non-responsiveness.
Purpose of the Study:
- To determine the frequency of aspirin non-responsiveness or resistance in patients with ischemic heart disease.
- To identify potential risk factors associated with aspirin resistance in this population.
Main Methods:
- Whole blood platelet aggregation studies were conducted on 71 IHD patients.
- Aspirin response assay using arachidonic acid determined non-responsiveness (Surface Covered <2.5%).
- Chi-square test was used for statistical analysis of risk factors.
Main Results:
- Aspirin non-response was observed in 11% (8 out of 71) of the study cohort.
- A significant association was found between aspirin resistance and diabetes mellitus (p=0.045).
- Aspirin treatment resistance was also significantly associated with female gender (p=0.015).
Conclusions:
- A significant proportion of ischemic heart disease patients exhibit non-response to aspirin therapy.
- Diabetes mellitus and female gender are identified as strong risk factors for aspirin treatment failure.
Abstract:
Aspirin is widely used as an antiplatelet agent . Many patients have been noticed with recurrence of major ischemic events in- spite of antiplatelet therapy. The objective of this study was to determine frequency of aspirin non-responsiveness /resistance in patients of ischemic heart disease. Seventy one patients of IHD were selected from out-patient department of Punjab Institute of Cardiology Lahore. Whole Blood Platelet aggregation studies were performed on Diamed Impact R. Aspirin response assay was performed with DiaChidon (Arachidoinc Acid 16mmol/L). Non responders to aspirin were assessed on the basis of software generated results: Surface covered (SC) >2.5% was considered as response to aspirin and SC <2.5% was considered as no response (or resistance) to Aspirin. Chi-square test was applied to measure statistical significance. Non-response to Aspirin was observed in 11% (8 out of 71). There was significant association (p=0.045) between resistance to aspirin and Diabetes mellitus. Treatment resistance was also significantly associated with female gender (p=0.015). We concluded that non response to Aspirin is seen in significant number of patients of IHD. Diabetes mellitus and female gender are strong risk factors of developing failure to aspirin therapy.
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