Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Endocrine Signaling01:45

Endocrine Signaling

68.0K
Endocrine cells produce hormones to communicate with remote target cells found in other organs. The hormone reaches these distant areas using the circulatory system. This exposes the whole organism to the hormone but only those cells expressing hormone receptors or target cells are affected. Thus, endocrine signaling induces slow responses from its target cells but these effects also last longer.
68.0K
What is the Endocrine System?00:46

What is the Endocrine System?

420.2K
The endocrine system sends hormones—chemical signals—through the bloodstream to target cells—the cells the hormones selectively affect. These signals are produced in endocrine cells, secreted into the extracellular fluid, and then diffuse into the blood. Eventually, they diffuse out of the blood and bind to target cells which have specialized receptors to recognize the hormones.
420.2K
The Endocrine System01:29

The Endocrine System

1.3K
The endocrine system is an extensive network of glands – organs or tissues in the body that create chemicals that control many bodily functions, that secrete hormones, which are chemical messengers that play essential roles in regulating various bodily functions. These hormones are secreted into the bloodstream and travel throughout the body. They require specific receptors to convey signals to cells possessing these corresponding receptors. This complex signaling mechanism ensures that...
1.3K
An Overview of the Endocrine System01:10

An Overview of the Endocrine System

13.6K
The endocrine system, a complex network of glands, orchestrates physiological balance within the body through the production and secretion of hormones. These hormones are chemical messengers in intercellular communication, acting as conduits between the secretory cells and distant target sites. They traverse the circulatory system by being released into the extracellular fluid, and their impact is specific to cells possessing receptors for a particular hormone.
The endocrine system collaborates...
13.6K
Structures of the Endocrine System00:59

Structures of the Endocrine System

11.8K
The intricate framework of the endocrine system encompasses a diverse array of glands, with their target tissues and organs strategically distributed throughout the body. Central to this network are the endocrine glands, specialized structures that lack ducts and release hormones directly into the interstitial fluid. Notably, the hypothalamus, a vital neuroendocrine organ situated in the brain, governs neural functions and serves as a potent source of hormonal regulation. Near the hypothalamus...
11.8K
Chemical Signaling in the Endocrine System01:08

Chemical Signaling in the Endocrine System

6.3K
A signaling cascade is a series of events that facilitates the transmission of information within or between cells, culminating in a targeted response in the recipient cell. As chemical messengers, hormones are pivotal in initiating and modulating these intricate signaling cascades based on their solubility.
Lipid-soluble hormones, such as steroid hormones, demonstrate an intracellular action. These hormones traverse cell membranes due to their lipid nature. Once inside the target cell, they...
6.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of pasteurized <i>Akkermansia muciniphila</i> MucT on insulin sensitivity, body composition, and GLP-1 production in subjects with metabolic syndrome: impact of low baseline gut <i>Akkermansia</i> levels.

Gut microbes·2026
Same author

Metabolic state determines the brain and direct islet effects of liraglutide on enhanced insulin secretion.

Diabetologia·2026
Same author

Link between ultra-processed foods and drinks intake, gut microbiota and inflammation: an exploratory analysis in adult volunteers.

Nutrition journal·2026
Same author

The Effects of a Powdered Meal Replacement on Inflammation, Gut Microbiota, and Metabolism in People With Excess Body Weight-A Randomized Controlled Trial.

The Journal of nutrition·2026
Same author

Breath volatilome analysis reveals new gut microbiome-related metabolites that discriminate high versus low dietary fibre intake.

Clinical nutrition (Edinburgh, Scotland)·2026
Same author

The lipid transfer protein STARD7 controls intestinal tumor development in a context-dependent manner.

EMBO molecular medicine·2026

Related Experiment Video

Updated: Jan 25, 2026

Application of Flow Vermimetry for Quantification and Analysis of the Caenorhabditis elegans Gut Microbiome
08:38

Application of Flow Vermimetry for Quantification and Analysis of the Caenorhabditis elegans Gut Microbiome

Published on: March 31, 2023

1.1K

The Gut Microbiome Influences Host Endocrine Functions.

Marialetizia Rastelli1,2, Patrice D Cani1,2, Claude Knauf2,3

  • 1Université Catholique de Louvain, UCLouvain, Walloon Excellence in Life Sciences and BIOtechnology (WELBIO), Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Brussels, Belgium.

Endocrine Reviews
|May 14, 2019
PubMed
Summary

The gut microbiome regulates host metabolism through bacterial metabolites. These compounds influence gut peptides, amino acid metabolism, and neurotransmitters, impacting endocrine functions and overall health.

More Related Videos

A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis
09:18

A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis

Published on: July 28, 2023

3.5K
Co-culture of Living Microbiome with Microengineered Human Intestinal Villi in a Gut-on-a-Chip Microfluidic Device
10:51

Co-culture of Living Microbiome with Microengineered Human Intestinal Villi in a Gut-on-a-Chip Microfluidic Device

Published on: August 30, 2016

23.4K

Related Experiment Videos

Last Updated: Jan 25, 2026

Application of Flow Vermimetry for Quantification and Analysis of the Caenorhabditis elegans Gut Microbiome
08:38

Application of Flow Vermimetry for Quantification and Analysis of the Caenorhabditis elegans Gut Microbiome

Published on: March 31, 2023

1.1K
A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis
09:18

A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis

Published on: July 28, 2023

3.5K
Co-culture of Living Microbiome with Microengineered Human Intestinal Villi in a Gut-on-a-Chip Microfluidic Device
10:51

Co-culture of Living Microbiome with Microengineered Human Intestinal Villi in a Gut-on-a-Chip Microfluidic Device

Published on: August 30, 2016

23.4K

Area of Science:

  • Microbiology
  • Metabolism
  • Endocrinology

Background:

  • The gut microbiome is increasingly recognized as a key regulator of host metabolism.
  • Research has uncovered intricate molecular mechanisms linking gut bacteria to host cell interactions and metabolic outcomes.
  • Metagenomic and metabolomic analyses are crucial for identifying bacterial metabolites that influence host physiology.

Purpose of the Study:

  • To review the molecular mechanisms by which bacterial metabolites regulate host metabolism.
  • To highlight the role of specific microbial metabolites, including short-chain fatty acids and amino acid derivatives, in host metabolic control.
  • To discuss the influence of gut microbes on the endocannabinoid system and neurotransmitter production.

Main Methods:

  • Literature review of studies investigating gut microbiome-host metabolism interactions.
  • Analysis of molecular mechanisms involving bacterial metabolites as paracrine or endocrine factors.
  • Examination of findings related to short-chain fatty acids, amino acid metabolites, bioactive lipids, neurotransmitters, and bacterial components.

Main Results:

  • Bacterial metabolites, such as short-chain fatty acids, modulate the secretion of gut peptides like glucagon-like peptide-1 and peptide YY.
  • Microbial metabolites derived from amino acids play roles in regulating inflammation, glucose metabolism, and energy homeostasis.
  • Gut microbes influence host metabolism through modulation of the endocannabinoid system, neurotransmitters (e.g., GABA, serotonin), and bacterial components (e.g., ClpB, Amuc_1100).

Conclusions:

  • The gut microbiome significantly influences host endocrine functions through a variety of bacteria-derived metabolites.
  • Understanding these microbial-host metabolic crosstalk mechanisms is vital for developing novel therapeutic strategies.
  • Bacterial metabolites act as critical signaling molecules, bridging the gut microbial community and host metabolic regulation.