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Current insights into the epigenetic mechanisms of skin cancer

Yanqi Sang1, Yu Deng1

  • 1Department of Environmental Health, School of Public Health, China Medical University, Shenyang, Liaoning, People's Republic of China.

Dermatologic Therapy
|May 14, 2019
PubMed

Insights

Epigenetic modifications play a crucial role in skin cancer development. This review explores DNA methylation, histone modifications, and RNA methylation in squamous cell carcinoma, basal cell carcinoma, and melanoma.

Area of Science:

  • Oncology
  • Epigenetics
  • Dermatology

Background:

  • Skin cancer encompasses squamous cell carcinoma, basal cell carcinoma, and melanoma, each with distinct characteristics.
  • Epigenetic modifications, such as DNA and RNA methylation and histone alterations, influence gene expression without changing DNA sequence.
  • These epigenetic changes are implicated in the development of different skin cancer types.

Purpose of the Study:

  • To review the role of epigenetics in skin cancer.
  • To examine epigenetic modifications in squamous cell carcinoma, basal cell carcinoma, and melanoma.
  • To focus on DNA methylation, histone modifications, and RNA methylation in skin carcinogenesis.

Main Methods:

  • Literature review of epigenetic mechanisms in skin cancer.
  • Analysis of studies on DNA methylation patterns in skin tumors.
  • Examination of research on histone modifications and RNA methylation in skin carcinogenesis.

Main Results:

  • Epigenetic alterations differ across skin cancer types.
  • DNA methylation, histone modifications, and RNA methylation are key epigenetic processes in skin cancer.
  • These modifications contribute to heritable changes in gene expression.

Conclusions:

  • Epigenetics is integral to understanding skin cancer biology.
  • Targeting epigenetic modifications offers potential therapeutic strategies for skin cancer.
  • Further research into specific epigenetic mechanisms is warranted for all skin cancer types.
Keywords:
RNA methylationepigeneticsskin cancer

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