Multiple myeloma associated with the heavy chains of immunoglobulin A in a dog

On the basis of microscopic evaluation of bone marrow aspirate, multiple myeloma and secondary marrow hypoplasia was diagnosed in a 7-year-old female Doberman Pinscher. Electrophoresis, radial gel diffusion, and immunoaffinity chromatography indicated that serum and urine specimens contained alpha immunoglobulins without kappa or lambda light chains. Whole immunoglobulins (Ig) A, IgG, or IgM were not found. The dog was treated with prednisolone and melphalan for 11 weeks, after which time the owner refused examination and treatment of the dog.