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Updated: Jan 25, 2026

Preparation of SNS CobaltII Pincer Model Complexes of Liver Alcohol Dehydrogenase
Published on: March 19, 2020
Cobalt-Catalyzed Diastereoselective Difluoroalkylation/Giese Addition Domino Reactions
Shengnan Han1, Shaodong Liu1, Lei Liu1
1School of Pharmaceutical Sciences , Jiangnan University , Lihu Road 1800 , 214122 Wuxi , Jiangsu , China.
Abstract:
An efficient cobalt-catalyzed difluoroalkylation/Giese radical conjugate cyclization manifold with various alkyne-tethered cyclohexadienones and halogenated fluorinating reagents was accomplished under remarkable mild reaction conditions, thus providing an expedient route to valuable fluorinated chromens. The utility of this transformation was demonstrated by high site selectivity as well as chemo- and diastereoselectivity, broad substrate scope, excellent functional group tolerance, and facile late-stage modification.
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