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Cobalt Catalyzed Hydroarylation of Michael Acceptors with Indolines Directed by a Weakly Coordinating Functional
Shyam Kumar Banjare1, Rajesh Chebolu1, P C Ravikumar1
1School of Chemical Sciences , National Institute of Science Education and Research (NISER) Bhubaneswar, HBNI , Jatani , Khurda, 752050 Odisha , India.
Abstract:
A cobalt(III) catalyzed hydroarylation of Michael acceptors using indolines, selectively at the C-7 position, has been reported. For the selective C-7 functionalization of indoline, we have used a weakly coordinating amide carbonyl group. During the process of optimization, we have also discovered the unusual cocatalytic activity of zinc triflate in the C-H functionalization reaction. Hydroarylation of unprotected maleimide using indolines was a challenging substrate and never accomplished before, we were able to achieve this with our methodology in good yields.
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