Related Experiment Video

Updated: Jan 25, 2026

A Novel Approach to Overcome Movement Artifact When Using a Laser Speckle Contrast Imaging System for Alternating Speeds of Blood Microcirculation
07:20

A Novel Approach to Overcome Movement Artifact When Using a Laser Speckle Contrast Imaging System for Alternating Speeds of Blood Microcirculation

Published on: August 30, 2017

8.8K

Cutaneous microvascular function in patients with obstructive or non-obstructive coronary artery disease evaluated by

Jian Zhao1, Na Li1, Jiamei Wang1

  • 1Department of Cardiology, Changzheng Hospital, Second Military Medical University, Shanghai, China.

Microvascular Research
|May 15, 2019
PubMed

Insights

Non-obstructive coronary artery disease (CAD) patients show reduced cutaneous microvascular function compared to obstructive CAD patients and healthy controls. This suggests potential differences in underlying mechanisms of myocardial ischemia.

Area of Science:

  • Cardiovascular Research
  • Microvascular Physiology
  • Medical Imaging

Background:

  • Coronary artery disease (CAD) affects millions globally, with varying clinical presentations.
  • Understanding microvascular function is crucial for assessing cardiovascular health.
  • Non-obstructive CAD (NObCAD) and obstructive CAD (ObCAD) may involve different pathophysiological pathways.

Purpose of the Study:

  • To compare cutaneous microvascular reactivity between patients with ObCAD, NObCAD, and healthy controls.
  • To investigate the utility of laser speckle contrast imaging (LSCI) and post-occlusive reactive hyperemia (PORH) in assessing microvascular dysfunction in CAD.
  • To explore potential differences in microvascular function as indicators of underlying ischemia mechanisms.

Main Methods:

  • Utilized laser speckle contrast imaging (LSCI) to measure cutaneous blood flow.
  • Assessed microvascular function through post-occlusive reactive hyperemia (PORH).
  • Categorized CAD patients into ObCAD (n=133) and NObCAD (n=129) groups based on coronary angiography, comparing them to healthy controls (n=83).

Main Results:

  • Significantly reduced microvascular reactivity was observed in the NObCAD group compared to controls and the ObCAD group (p < 0.05).
  • ObCAD patients exhibited attenuated PORH responses compared to controls, though not statistically significant (p > 0.05).
  • LSCI and PORH effectively differentiated microvascular function between CAD subgroups and controls.

Conclusions:

  • NObCAD patients are more prone to developing cutaneous microvascular dysfunction than ObCAD patients.
  • Cutaneous microvascular dysfunction may serve as a biomarker reflecting distinct mechanisms of myocardial ischemia in different CAD phenotypes.
  • Further research into microvascular assessment in CAD is warranted.
Abstract

Keywords:
Cutaneous microvascular functionLaser speckle contrast imagingNon-obstructive coronary artery diseaseObstructive coronary artery disease

More Related Videos

How to Build a Laser Speckle Contrast Imaging LSCI System to Monitor Blood Flow05:24

How to Build a Laser Speckle Contrast Imaging LSCI System to Monitor Blood Flow

Published on: November 11, 2010

24.5K
A Mouse Model to Evaluate the Long-Term Structural and Functional Outcomes after the Reversal of Prolonged Unilateral Ureteric Obstruction05:34

A Mouse Model to Evaluate the Long-Term Structural and Functional Outcomes after the Reversal of Prolonged Unilateral Ureteric Obstruction

Published on: July 18, 2025

508

Related Concept Videos

Chronic Obstructive Pulmonary Disease01:22

Chronic Obstructive Pulmonary Disease

COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
2.4K
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
4.3K
Chronic Obstructive Pulmonary Disease-I: Introduction01:20

Chronic Obstructive Pulmonary Disease-I: Introduction

Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
3.6K
Chronic Obstructive Pulmonary Disease-V: Management01:29

Chronic Obstructive Pulmonary Disease-V: Management

Managing Chronic Obstructive Pulmonary Disease (COPD) involves a multifaceted approach to reduce symptoms, prevent exacerbations, improve overall health status, and slow disease progression. Key strategies include lifestyle modifications, pharmacotherapy, supportive therapies, and, in some cases, surgery. Here is an overview of the primary COPD management strategies:
Smoking Cessation
3.1K
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
934
Chronic Obstructive Pulmonary Disease-V: Nursing Management01:30

Chronic Obstructive Pulmonary Disease-V: Nursing Management

Nursing management of Chronic Obstructive Pulmonary Disease (COPD) is crucial for providing thorough care and support to patients. Nurses play an integral role in this process through detailed assessment, careful planning, targeted interventions, and ongoing evaluation. Here's an overview of the critical steps in nursing management for COPD.
Assessment
5.1K