Associations between UGT2B7 polymorphisms and cancer susceptibility: A meta-analysis
Ming-Li Shen1, An Xiao2, Sun-Jun Yin3
1Institute of Pharmacy and Chemistry, Dali University, Dali 671000, China; Department of Pharmacy, 920th Hospital of Joint Logistics Support Force, Kunming 650032, China.
Gene
|May 15, 2019
Summary
This meta-analysis found that the UGT2B7 rs7439366 polymorphism is associated with increased colorectal cancer risk. This finding suggests UGT2B7 single nucleotide polymorphisms (SNPs) could be biomarkers for colorectal cancer prediction.
Area of Science:
- Genetics and Genomics
- Cancer Research
- Pharmacogenomics
Background:
- The UGT2B7 enzyme is crucial for metabolizing carcinogens.
- UGT2B7 gene polymorphisms are linked to carcinogen metabolism.
- Previous studies on UGT2B7 single nucleotide polymorphisms (SNPs) and cancer risk have yielded conflicting results.
Purpose of the Study:
- To conduct a meta-analysis to clarify the association between UGT2B7 SNPs and cancer susceptibility.
- To investigate the role of specific UGT2B7 SNPs in various cancer types.
Main Methods:
- A comprehensive literature search was performed across multiple databases (PubMed, EMBASE, Cochrane, CNKI, VIP, Wan Fang) up to March 2019.
- Meta-analysis was conducted using Review Manager 5.3.
- Subgroup analyses were performed based on cancer type, ethnicity, and control group source.
Main Results:
- The meta-analysis included 13 studies with 7688 cancer cases and 11,281 controls.
- UGT2B7 rs7439366 polymorphism was significantly associated with increased colorectal cancer risk under a dominant model (OR=0.76, P=0.02).
- No significant associations were found for rs7435335 and rs12233719 with cancer risk. rs7441774 and rs3924194 showed potential associations with breast and papillary thyroid cancer, respectively, but require further validation due to limited study inclusion.
Conclusions:
- The UGT2B7 rs7439366 SNP is confirmed to be associated with colorectal cancer risk.
- UGT2B7 rs7439366 may serve as a potential biomarker for predicting colorectal cancer risk.
- Further research is needed to validate associations for other investigated UGT2B7 SNPs.
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