Structure-activity relationship and synthetic methodologies of α-santonin derivatives with diverse bioactivities: A
Jiangming Wang1, Siyuan Su1, Shangzhe Zhang1
1College of Food Science and Technology, Shanghai Ocean University, Shanghai, 201306, China.
Abstract:
α-Santonin, a sesquiterpene lactone isolated from Artemisia Santonica, possesses diverse bioactivities including antioxidant, anti-inflammation, immunosuppressive, anti-roundworm, anti-malaria, etc. However, its bioactivities are not satisfactory and need to be further optimized. Thus, many α-santonin derivatives were synthesized on the basis of rings A, B and C for the discovery of new analogues with prominent bioactivities. Herein, we reviewed and discussed the related synthetic methodologies, diverse bioactivities and structure-activity relationships (SAR) of α-santonin derivatives.
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