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Updated: Jan 25, 2026
04:37
Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension
Published on: June 6, 2025
700
Management of resistant hypertension
Mohanad A Hasan1, Merrill H Stewart, Carl J Lavie
1John Ochsner Heart and Vascular Institute, Ochsner Clinical School-the University of Queensland School of Medicine, New Orleans, Louisiana, USA.
Current Opinion in Cardiology
|May 15, 2019
Summary
Resistant hypertension management requires evaluating for pseudoresistance and secondary causes. Treatment involves lifestyle changes, diuretics, mineralocorticoid receptor antagonists, and potentially advanced therapies like renal denervation.
Area of Science:
- Cardiology
- Nephrology
- Internal Medicine
Background:
- Resistant hypertension, defined as uncontrolled blood pressure despite optimal multi-drug therapy, is a growing clinical concern.
- It significantly elevates the risk of cardiovascular disease, necessitating effective management strategies.
Purpose of the Study:
- To review current approaches to managing resistant hypertension.
- To highlight the importance of identifying pseudoresistance and secondary causes.
- To discuss therapeutic options including diuretics, antagonists, and interventional therapies.
Main Methods:
- Literature review of recent findings on resistant hypertension.
- Analysis of diagnostic criteria and management guidelines.
- Evaluation of evidence for pharmacological and interventional treatments.
Main Results:
- Pseudoresistance factors like poor adherence and white coat hypertension must be ruled out.
- Thiazide diuretics and mineralocorticoid receptor antagonists are key therapeutic agents.
- Secondary causes necessitate tailored treatment, alongside lifestyle modifications.
Conclusions:
- Comprehensive evaluation for pseudoresistance and secondary causes is crucial for resistant hypertension.
- Pharmacological strategies should include diuretics and mineralocorticoid receptor antagonists.
- Emerging interventional therapies offer additional options for challenging cases.
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