Related Experiment Video
Updated: Jan 25, 2026
Murine Fecal Isolation and Microbiota Transplantation
Published on: May 26, 2023
Fecal Microbiota Transplant for Irritable Bowel Syndrome: Panacea or Placebo?
Aasma Shaukat1, Darren M Brenner2
1Department of Medicine, Section of Gastroenterology Minneapolis VA Medical Center and University of Minnesota, Minneapolis, Minnesota, USA.
Abstract:
Irritable bowel syndrome (IBS) is a common disorder of heterogeneous pathogenesis, and alterations in the gut microbiome/dysbiosis play a role in the development of symptoms in a subset of individuals with IBS. Consequently, it stands to reason that modulation of the microbiome via fecal microbial transplant (FMT) may serve as an effective treatment strategy because this has proven effective for treating other illnesses such as Clostridium difficile colitis. Small studies completed to date have offered conflicting results and the strains used, route of administration, and IBS subtypes may all play a role in treatment outcomes. A better understanding of the altered microbiome of patients with IBS and more rigorous trials are warranted before the utility of fecal microbial transplant for IBS symptoms can be determined.
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