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Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis
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Antipsychotics Do Not Influence Neurological Soft Signs in Children and Adolescents at Ultra-High Risk for Psychosis:
Journal of Psychiatric Practice
|May 15, 2019
Summary
Neurological soft signs (NSS) are more prevalent in ultra-high risk for psychosis (UHR) youth. Antipsychotic treatment did not alter NSS in these early-treated UHR children and adolescents.
Area of Science:
- Neuroscience
- Psychiatry
- Developmental Psychology
Background:
- Ultra-high risk for psychosis (UHR) is a prodromal state preceding psychotic disorders.
- Neurological soft signs (NSS) are motor abnormalities associated with schizophrenia and may represent an endophenotype.
- The effect of antipsychotics on NSS in UHR youth is largely unknown.
Purpose of the Study:
- To evaluate NSS in treated UHR subjects compared to drug-naive UHR subjects and healthy controls.
- To assess the impact of early antipsychotic treatment on NSS in UHR children and adolescents.
Main Methods:
- Cross-sectional study design.
- Involved 15 treated UHR subjects, 15 drug-naive UHR subjects, and 25 healthy controls.
- NSS were evaluated in all participants.
Main Results:
- Both UHR groups exhibited significantly more NSS than healthy controls.
- No significant differences in NSS were observed between treated and drug-naive UHR subjects.
- Antipsychotic treatment did not influence NSS in the early-treated UHR group.
Conclusions:
- Antipsychotic medications do not appear to affect NSS in UHR children and adolescents.
- Findings align with observations in first-episode psychosis and schizophrenia populations.
- NSS may be a stable endophenotype, unaffected by early antipsychotic intervention.
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