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Updated: Jan 25, 2026

Mobile Game-based Virtual Reality Program for Upper Extremity Stroke Rehabilitation
Published on: March 8, 2018
Improving neuropsychiatric symptoms following stroke using virtual reality: A case report
Rosaria De Luca1, Alfredo Manuli, Carmen De Domenico
1IRCCS Centro Neurolesi "Bonino-Pulejo", Messina, Italy.
Virtual reality combined with standard relaxation techniques significantly improved anxiety and cognitive deficits in a stroke patient. This approach offers a promising avenue for post-stroke rehabilitation, enhancing patient well-being and recovery outcomes.
Area of Science:
- Neuroscience
- Psychology
- Rehabilitation Medicine
Background:
- Post-stroke cognitive impairment affects 20-80% of stroke survivors, frequently accompanied by anxiety, which diminishes quality of life.
- Standard relaxation techniques show some efficacy in managing post-stroke anxiety during rehabilitation.
- Virtual reality (VR) demonstrates potential in treating anxiety disorders, particularly those linked to neurological damage.
Observation:
- A 50-year-old female smoker with hypertension experienced chronic anxiety and mild cognitive deficits (attention, visuo-executive functions) 12 months post-right ischemic stroke, alongside mild left hemiparesis.
- The patient presented with a severe anxiety state and mild cognitive impairment, impacting daily functioning.
Findings:
- A combined approach using standard relaxation techniques within an immersive virtual reality environment (Computer Assisted Rehabilitation Environment - CAREN) was implemented.
- Cognitive and psychological assessments before and after interventions revealed significant improvements in functional and behavioral outcomes solely after the combined VR-enhanced approach.
Implications:
- Immersive VR, specifically the CAREN system, shows promise as an effective tool for enhancing cognitive and psychological status in post-stroke individuals.
- This innovative approach may offer a superior method for managing anxiety symptoms and improving cognitive function in stroke survivors compared to standard methods alone.
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