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A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis
Published on: March 14, 2025
Oseltamivir induced Stevens-Johnson syndrome/toxic epidermal necrolysis-case report
Wei Zuo1,2, Li-Ping Wen1, Jun Li1
1Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing.
Rationale:
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are 2 rare but life-threatening diseases characterized by detachment of epidermis, bullous skin lesions, and mucous membrane erosions. Drugs are highly suspected to be the causative agents. We report a case of SJS/TEN induced by oseltamivir, which is a very rare event.
Patient Concerns:
A 9-year-old girl with upper respiratory tract infections presented with generalized maculopapular rash the second day after taking oseltamivir.
Diagnosis:
The diagnosis of SJS/TEN was made based on cytotoxic skin lesions and mucous membrane involvement.
Interventions:
After discontinuing of the drug and combination therapy of corticosteroid and human immunoglobulin initiation, the lesions were improved. Human leukocyte antigen (HLA) gene sequencing was done.
Outcomes:
The girl was followed-up for 1 year. The skin and mucous membranes symptoms were relieved.
Lessons:
We report this case to attract attention to the rare but serious side effect of this antiviral drug.
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