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Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives

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Published on: January 19, 2016

Glycerol and Q-Tubes: Green Catalyst and Technique for Synthesis of Polyfunctionally Substituted Heteroaromatics and

Douaa Salman AlMarzouq¹, Noha M Hilmy Elnagdi²

¹Department of Environmental Health, College of Health Sciences, the Public Authority of Applied Education and Training, P.O. Box 23167, Safat 13092, Kuwait. nontan_83@hotmail.com.

Molecules (Basel, Switzerland)

|May 15, 2019

Abstract:

The role of glycerol as a green bio-based solvent, reactant, and/or a catalyst in the synthesis of novel heterocycles, under pressure, is studied. Synthesis of novel quinolines in good yields using a new modified Skraup synthesis, utilizing glycerol and pressure Q-tubes, is demonstrated. Novel aniline trimers are prepared using glycerol, and substituted anilines under pressure, in acidic medium and water. Glycerol was employed as a catalyst and a green solvent in the synthesis of novel pyridazines 13a-c. The mechanisms of the reactions and the catalytic effect of glycerol in protic and aprotic media are fully discussed. The structures of the synthesized compounds were determined via X-ray crystallography and spectroscopic methods.

Keywords:

Q-tubes glycerol green chemistry modified Skraup’s quinoline synthesis polyaniline reactions under pressure

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