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Grb7, a Critical Mediator of EGFR/ErbB Signaling, in Cancer Development and as a Potential Therapeutic Target

Pei-Yu Chu1, Yu-Ling Tai2,3, Tang-Long Shen4,5

  • 1Department of Plant Pathology and Microbiology, National Taiwan University, Taipei 10617, Taiwan. areteka@gmail.com.

Cells
|May 15, 2019
PubMed

Insights

Growth factor receptor bound protein-7 (Grb7) is crucial in ERBB family-mediated cancers. Overexpression of Grb7 indicates poor prognosis and recurrence, highlighting its potential as a therapeutic target.

Area of Science:

  • Molecular biology
  • Oncology
  • Signal transduction

Background:

  • Growth factor receptor bound protein-7 (Grb7) is a multidomain adaptor protein interacting with signaling molecules.
  • Grb7 plays a key role in epidermal growth factor receptor (EGFR) signaling pathways.
  • Grb7 is implicated in various physiological and pathological processes.

Purpose of the Study:

  • To review the molecular, functional, and clinical aspects of Grb7.
  • To explore Grb7's role in ERBB family-mediated cancer development and malignancy.
  • To identify alternative and effective therapeutic strategies targeting Grb7.

Main Methods:

  • Literature review of molecular, functional, and clinical studies on Grb7.
  • Analysis of Grb7's interactions with signaling molecules and pathways.
  • Evaluation of Grb7's role in cancer development and its association with ERBB family members.

Main Results:

  • Grb7 overexpression or coamplification with ERBB family members is observed in advanced human cancers.
  • Grb7's role is critical in ERBB family-mediated cancer development and malignancy.
  • High Grb7 levels correlate with decreased survival and increased cancer recurrence.

Conclusions:

  • Grb7 is a valuable prognostic marker and therapeutic target in ERBB family-mediated cancers.
  • Peptide inhibitors of Grb7 are under preclinical investigation.
  • Further research into Grb7's role may reveal novel therapeutic strategies.
Keywords:
ERBB familycancer developmentepidermal growth factor receptorgrowth factor receptor bound protein-7prognostic markertherapeutic target

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