Patient Derived Chicken Egg Tumor Model (PDcE Model): Current Status and Critical Issues

Area of Science:

• Oncology
• Developmental Biology
• Animal Models

Background:

• The chorioallantoic membrane assay (CAM assay) in chicken eggs is established for studying tumor formation, angiogenesis, and metastasis.
• There is increasing recognition of the CAM assay's utility as a patient-derived tumor model.
• Successful tumor reproduction from human cancer patient samples in chicken eggs has been reported with high transplantation efficiency.

Purpose of the Study:

• To review the application of patient-derived tumors in the chicken egg model.
• To discuss critical considerations for advancing research using this model.
• To highlight the potential of the patient-derived chicken egg model (PDcE model) in personalized cancer therapy.

Main Methods:

• Utilizing fertilized chicken eggs for tumor xenotransplantation.
• Employing the chorioallantoic membrane as a substrate for tumor growth.
• Reviewing existing literature on patient tumor transplantation in this model.

Main Results:

• Demonstrated feasibility of transplanting patient tumors into chicken eggs.
• Achieved high efficiency in tumor engraftment and growth.
• Observed rapid tumor formation in the patient-derived chicken egg model (PDcE model).

Conclusions:

• The patient-derived chicken egg model (PDcE model) is a rapid and effective system for preclinical cancer research.
• This model holds significant potential for personalized medicine, aiding in the selection of optimal drugs for individual cancer patients.
• Further research addressing critical issues is warranted to fully leverage the capabilities of the PDcE model.