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Related Experiment Videos

Mitochondrial Dysfunction in Parkinson's Disease-Cause or Consequence?

Chun Chen1,2, Doug M Turnbull3,4, Amy K Reeve5,6

  • 1Wellcome Centre for Mitochondrial Research, Institute for Neuroscience, Newcastle University Institute for Ageing, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK. c.chen20@ncl.ac.uk.

Biology
|May 15, 2019
PubMed
Summary

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This summary is machine-generated.

Mitochondrial dysfunction is central to Parkinson's disease (PD) neurodegeneration. Research suggests it may be a cause, not just a consequence, of neuronal loss in PD.

Area of Science:

  • Neuroscience
  • Pathology
  • Aging Research

Background:

  • Parkinson's disease (PD) involves motor symptoms first described over 200 years ago.
  • The exact cause of PD neurodegeneration and its selective occurrence with age remains unknown.
  • Mitochondrial dysfunction is a detected change in PD, but its role as cause or consequence is debated.

Purpose of the Study:

  • To review literature and discuss whether mitochondrial dysfunction is a pathogenic cause of neuronal loss in Parkinson's disease.
  • To differentiate between primary mitochondrial dysfunction and secondary effects from other pathway dysfunctions in PD.
  • To compare findings in idiopathic PD, familial PD, model systems, and healthy aging individuals.

Main Methods:

  • Literature review of current research on Parkinson's disease.
Keywords:
Parkinson’s diseaseageingmitochondrianeurodegenerative disease

Related Experiment Videos

  • Analysis of data from idiopathic PD cases, familial PD, and PD model systems.
  • Inclusion of data from healthy aged individuals for comparative analysis.

    • Main Results:

    • Mitochondrial dysfunction is consistently detected in Parkinson's disease.
    • Similar age-related changes are observed in healthy aging individuals, but typically without severe neurodegeneration.
    • The data suggests mitochondrial dysfunction is a prominent factor in the neurodegenerative pathway of PD.

    Conclusions:

    • Mitochondrial dysfunction plays a central role in the neurodegenerative process of Parkinson's disease.
    • While not definitively proven as the sole cause, its prominent position in the disease pathway is clear.
    • Further research is needed to fully elucidate the causal relationship between mitochondrial dysfunction and PD.