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Related Experiment Videos

A receptor for IgA on human T lymphocytes.

L G Lum, A V Muchmore, D Keren

    Journal of Immunology (Baltimore, Md. : 1950)
    |January 1, 1979
    PubMed
    Summary

    Human T cells possess receptors for immunoglobulin A (IgA) antibody-antigen complexes. These IgA receptors are distinct from other Fc receptors and their expression increases during cell culture.

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    Area of Science:

    • Immunology
    • Cell Biology
    • T cell receptor research

    Background:

    • T cells play a crucial role in adaptive immunity.
    • Antibody receptors on immune cells are vital for immune complex recognition.
    • Previous research has identified Fc receptors for IgG and IgM on T cells.

    Purpose of the Study:

    • To investigate the presence and characteristics of immunoglobulin A (IgA) receptors on human peripheral blood T cells.
    • To determine if IgA receptors on T cells are distinct from other Fc receptors (Fc-IgM, Fc-IgG).
    • To analyze the expression kinetics of IgA receptors on T cells in culture.

    Main Methods:

    • Flow cytometry was used to detect IgA receptors on human peripheral blood T cells.
    • Blocking studies with purified IgA, IgG, and IgM were performed to differentiate receptor types.

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  • T cells were cultured for 18-24 hours to observe receptor expression changes.

    • Main Results:

    • Receptors for IgA antibody-antigen complexes were identified on 2-18% (mean 6.7%) of human peripheral blood T cells.
    • The proportion of T cells expressing IgA receptors increased after 18-24 hours of culture.
    • Blocking studies confirmed that these IgA receptors are distinct from Fc-IgM and Fc-IgG receptors.

    Conclusions:

    • Human T cells express specific receptors for IgA antibody-antigen complexes.
    • These IgA receptors are immunologically distinct from Fc receptors for IgM and IgG.
    • The expression of IgA receptors on T cells is modulated by cell culture conditions.