Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacokinetics: Drug–Drug Interactions01:25

Pharmacokinetics: Drug–Drug Interactions

399
Drug interactions occur when the pharmacological effect of one drug is altered by another substance, either enhancing or diminishing its activity. The drug whose activity is altered is known as the object drug, and the substance causing the alteration is called the agent drug or the precipitant. The net effects of these interactions are mostly undesirable, leading to decreased effectiveness or increased adverse effects. In rare cases, interactions can be beneficial, such as the enhanced...
399
Pharmacokinetics: Drug–Food and Drug–Viral Interactions01:26

Pharmacokinetics: Drug–Food and Drug–Viral Interactions

226
A drug interaction occurs when the concurrent use of another drug, food, or an external substance alters the pharmacological activity of a drug. This interaction can modify the action of the original drug, affecting its effectiveness and safety.Drug–food interactions are significant as they impact drug absorption, metabolism, and excretion. For example, grapefruit juice is a well-known disruptor of drug metabolism. It inhibits the cytochrome P450 3A4 enzyme, crucial for the metabolism of...
226
Drug-Receptor Interactions01:29

Drug-Receptor Interactions

7.4K
Drug-receptor interaction describes the binding of receptors by drugs, but not all drug-receptor interactions result in activation and tissue response. For instance, the binding of agonists activates the receptor to generate a cellular reaction, while antagonists bind to receptors without causing their activation.
Several parameters, such as the drug's affinity for its receptor and its efficacy, which is its ability to activate the receptor, determine the drug's effect on the tissue....
7.4K
Factors Affecting Protein-Drug Binding: Drug Interactions01:23

Factors Affecting Protein-Drug Binding: Drug Interactions

576
Drug interactions are a critical aspect of pharmacology and can occur when two or more drugs compete for the same binding site. This competition can result in one drug displacing another, altering the effect of the displaced drug. Drug interactions are complex processes that rely heavily on how much of the displacer drug is present and how strongly it can bind to the same sites as the displaced drug.
Displacement interactions can have varying outcomes, ranging from toxicity to virtually...
576
Factors Affecting Renal Clearance: Drug Distribution and Drug Interactions01:09

Factors Affecting Renal Clearance: Drug Distribution and Drug Interactions

522
Renal clearance plays a pivotal role in drug elimination from the body and can be influenced by drug distribution and interactions. Understanding these factors is crucial in pharmacology as they impact the effectiveness and duration of drug therapy.
One important factor is the relationship between renal clearance and the apparent volume of distribution. Renal clearance tends to be inversely proportional to the apparent volume of distribution. Drugs with an extensive distribution volume or those...
522
Drug-Receptor Interaction: Antagonist01:28

Drug-Receptor Interaction: Antagonist

5.0K
An antagonist is a drug that binds strongly to a receptor without activating it. An antagonist prevents other molecules, such as neurotransmitters or hormones, from binding to the receptor and triggering a cellular response. Such interaction effectively hinders the normal physiological processes mediated by the receptor, resulting in various pharmacological effects depending on the specific receptor targeted.
Antagonists can be classified as competitive or noncompetitive based on their...
5.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Chamber-specific chromatin architecture guides functional interpretation of disease-associated Cis-regulatory elements in human cardiomyocytes.

Nature communications·2026
Same author

Evaluation of continuous flow centrifugation as an alternative technique to sample microplastic from water bodies.

Marine environmental research·2019
Same author

Repetitive Transcorneal Alternating Current Stimulation Reduces Brain Idling State After Long-term Vision Loss.

Brain stimulation·2015
Same author

Letter: proton pump inhibitor treatment and increased mortality in cirrhotic patients.

Alimentary pharmacology & therapeutics·2015
Same author

[Cardiovascular pharmacotherapy. Risks and adverse effects].

Herz·2014
Same author

Transverse tubules are a common feature in large mammalian atrial myocytes including human.

American journal of physiology. Heart and circulatory physiology·2011

Related Experiment Video

Updated: Jan 25, 2026

Nanomechanics of Drug-target Interactions and Antibacterial Resistance Detection
11:56

Nanomechanics of Drug-target Interactions and Antibacterial Resistance Detection

Published on: October 25, 2013

14.7K

[Drug-drug Interactions You Should Know!]

N Voigt, K Ort, S Sossalla

    Pneumologie (Stuttgart, Germany)
    |May 15, 2019
    PubMed
    Summary

    Drug-drug interactions (DDI) pose a significant challenge due to increasing polypharmacy. This review covers pharmacodynamic and pharmacokinetic DDIs, offering tools to help clinicians prevent adverse effects and improve patient outcomes.

    Area of Science:

    • Pharmacology
    • Clinical Medicine
    • Drug Safety

    Background:

    • Polypharmacy is increasing due to multi-morbidity, leading to a rise in potential drug-drug interactions (DDIs).
    • Understanding DDIs is crucial for managing patient safety in modern medicine.
    • The complexity of DDIs requires accessible information for healthcare professionals.

    Purpose of the Study:

    • To review pharmacodynamic and pharmacokinetic drug-drug interactions.
    • To provide clinically relevant examples of DDIs.
    • To offer practical tools for clinicians to identify and prevent DDIs.

    Main Methods:

    • Review of existing literature on pharmacodynamic DDIs.
    • Comprehensive review of pharmacokinetic DDIs, including mechanisms like cytochrome P450 and p-glycoproteins.

    More Related Videos

    A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development
    07:02

    A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development

    Published on: February 11, 2019

    10.2K
    A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions
    07:40

    A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions

    Published on: May 27, 2021

    4.6K

    Related Experiment Videos

    Last Updated: Jan 25, 2026

    Nanomechanics of Drug-target Interactions and Antibacterial Resistance Detection
    11:56

    Nanomechanics of Drug-target Interactions and Antibacterial Resistance Detection

    Published on: October 25, 2013

    14.7K
    A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development
    07:02

    A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development

    Published on: February 11, 2019

    10.2K
    A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions
    07:40

    A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions

    Published on: May 27, 2021

    4.6K
  • Identification and compilation of tools for clinical practice.

    • Main Results:

    • Detailed explanation of pharmacodynamic DDIs with examples.
    • Extensive review of pharmacokinetic DDIs affecting drug plasma concentrations.
    • Presentation of practical tools for DDI identification and prevention.

    Conclusions:

    • Increased awareness and prevention strategies for DDIs are essential, especially in aging populations on polypharmacy.
    • Effective management of DDIs can reduce patient mortality and morbidity.
    • Clinicians can utilize provided tools to enhance patient safety by avoiding potential DDIs.