Related Experiment Video

Updated: Jan 25, 2026

A Rodent Model of The Ross Operation: Syngeneic Pulmonary Artery Graft Implantation in A Systemic Position
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A Rodent Model of The Ross Operation: Syngeneic Pulmonary Artery Graft Implantation in A Systemic Position

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Long-Term Fate of the Neoaortic Root After Neonatal Ross Operation: A Case Series

Nicola Pradegan1, Biagio Castaldi2, Danila Azzolina3

  • 11 Pediatric and Congenital Cardiac Surgery Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, Padua, Italy.

World Journal for Pediatric & Congenital Heart Surgery
|May 16, 2019
PubMed

Insights

The pulmonary autograft shows excellent long-term adaptation in children after the Ross procedure. This study confirms the viability of using infant pulmonary tissue for aortic valve replacement during growth.

Area of Science:

  • Cardiovascular Surgery
  • Pediatric Cardiology
  • Thoracic Surgery

Background:

  • The Ross operation is a surgical procedure for aortic valve disease.
  • Pulmonary autografts are used as a substitute for the aortic valve.
  • Long-term adaptation of infant pulmonary autografts during somatic growth requires further investigation.

Purpose of the Study:

  • To analyze the adaptation properties of the pulmonary autograft in infants undergoing the Ross operation.
  • To assess the long-term outcomes of pulmonary autografts in pediatric patients.

Main Methods:

  • Serial echocardiographic assessments of autograft diameters were performed.
  • Autograft diameters were reported as Z scores relative to normal aortic and pulmonary diameters.
  • Follow-up data was collected for a median of 18.5 years.

Main Results:

  • All patients survived the follow-up period.
  • No autograft reinterventions were required.
  • The pulmonary autograft demonstrated excellent adaptation and growth potential.

Conclusions:

  • The infant pulmonary autograft exhibits excellent long-term adaptation potential.
  • The Ross operation using a pulmonary autograft is a viable option for pediatric aortic valve replacement.
  • Pulmonary autografts can accommodate somatic growth in pediatric patients effectively.

Keywords:
Ross operationautograftinfantoutcomes

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