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Updated: Jan 25, 2026

Production and Detection of Reactive Oxygen Species ROS in Cancers
Published on: November 21, 2011
Redox Signaling Through Compartmentalization of Reactive Oxygen Species: Implications for Health and Disease
Andrew P Wojtovich1, Brandon J Berry2, Alexander Galkin3
11Department of Anesthesiology and Perioperative Medicine, University of Rochester Medical Center, Rochester, New York.
Abstract:
The cell maintains a balance between the production and removal of reactive oxygen species (ROS). Changes in ROS levels can impact many cellular functions, and dysregulation contributes to pathologies. How a specific cellular environment or microdomain influences the ROS-generating systems and biological impact of ROS remains an active area of research. This Forum highlights the complexity of ROS microdomains and their contributions to health and disease. Novel technologies to measure or generate ROS in defined regions are important developments in the spatial control of ROS. Using these advances, the articles herein demonstrate how site-specific redox environments influence cellular function and pathology. Antioxid. Redox Signal. 31, 591-593.
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