Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

992
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
992
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

2.0K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
2.0K
Principles of Disease Surveillance01:26

Principles of Disease Surveillance

486
Disease surveillance is the systematic collection, analysis, and interpretation of health data essential to the planning, implementation, and evaluation of public health practice. This process integrates data dissemination to entities responsible for preventing and controlling disease, injury, and disability. Surveillance systems provide crucial information for action, helping public health authorities make informed decisions to manage and prevent outbreaks, ensure public safety, optimize...
486
Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

1.0K
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
1.0K
Alzheimer's Disease: Treatment01:22

Alzheimer's Disease: Treatment

848
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
848
Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

434
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
434

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mohs micrographic surgery versus wide local excision for recurrent cutaneous squamous cell carcinoma.

JAAD international·2026
Same author

Single-Stage Revision of Alar Notching After Multiple Mohs Surgeries.

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]·2026
Same author

Reconstruction of a Large Periauricular Defect After Mohs Micrographic Surgery.

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]·2026
Same author

Prognostic determinants of early and late relapse in cutaneous squamous cell carcinoma: A multicenter retrospective cohort study.

Journal of the American Academy of Dermatology·2026
Same author

Mohs Surgery for Primary Melanoma in Situ Treated With Narrow Initial Margins: A Single-Center Review of 530 Tumors.

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]·2026
Same author

Metastatic Primary Extramammary Paget Disease: A Case Series.

Cutis·2026

Related Experiment Video

Updated: Jan 25, 2026

Author Spotlight: Exploring Non-Motor Symptoms in Parkinson's Disease
03:20

Author Spotlight: Exploring Non-Motor Symptoms in Parkinson's Disease

Published on: September 22, 2023

2.3K

Extramammary Paget Disease.

Bradley G Merritt1, Catherine A Degesys1, David G Brodland2

  • 1Department of Dermatology, University of North Carolina-Chapel Hill, 410 Market Street, Suite 400, Chapel Hill, NC 27516, USA.

Dermatologic Clinics
|May 16, 2019
PubMed
Summary
This summary is machine-generated.

Extramammary Paget disease is an intraepidermal cancer. While often treatable when limited to the skin, invasive forms require prompt management, with Mohs surgery being the preferred approach.

Keywords:
CK7 stainingExtramammary paget diseaseMohs micrographic surgery

More Related Videos

Author Spotlight: Establishing a New Fluorescence-Based Protocol for In Vivo Mitochondrial Morphology Analysis in Parkinson's Disease
06:07

Author Spotlight: Establishing a New Fluorescence-Based Protocol for In Vivo Mitochondrial Morphology Analysis in Parkinson's Disease

Published on: June 23, 2023

2.2K
Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.7K

Related Experiment Videos

Last Updated: Jan 25, 2026

Author Spotlight: Exploring Non-Motor Symptoms in Parkinson's Disease
03:20

Author Spotlight: Exploring Non-Motor Symptoms in Parkinson's Disease

Published on: September 22, 2023

2.3K
Author Spotlight: Establishing a New Fluorescence-Based Protocol for In Vivo Mitochondrial Morphology Analysis in Parkinson's Disease
06:07

Author Spotlight: Establishing a New Fluorescence-Based Protocol for In Vivo Mitochondrial Morphology Analysis in Parkinson's Disease

Published on: June 23, 2023

2.2K
Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.7K

Area of Science:

  • Dermatology
  • Surgical Oncology

Background:

  • Extramammary Paget disease (EMPD) is an intraepidermal adenocarcinoma.
  • Typically affects genital skin but can occur elsewhere.
  • Primary EMPD confined to the epidermis has a good prognosis, unlike invasive disease.

Purpose of the Study:

  • To review the diagnosis and management of Extramammary Paget disease.
  • To highlight the role of Mohs micrographic surgery.
  • To discuss alternative and emerging treatment modalities.

Main Methods:

  • Review of current literature on Extramammary Paget disease.
  • Emphasis on surgical excision, particularly Mohs micrographic surgery.
  • Discussion of non-surgical treatments and diagnostic aids like cytokeratin 7.

Main Results:

  • Surgical excision, especially Mohs surgery, is the primary treatment for EMPD.
  • Topical therapies, photodynamic therapy, laser, chemotherapy, and radiation have limited data.
  • Cytokeratin 7 immunostaining improves detection on frozen sections.

Conclusions:

  • Mohs micrographic surgery is the gold standard for treating Extramammary Paget disease.
  • Early diagnosis and complete excision are crucial for favorable outcomes.
  • Further research is needed for non-surgical treatment options.