Related Experiment Video

Updated: Jan 25, 2026

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice
07:54

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice

Published on: December 21, 2019

7.3K

Loco-regional staging of malignant pleural mesothelioma by integrated 18F-FDG PET/MRI

D J Murphy1, S M Mak2, A Mallia1

  • 1King's College London & Guy's and St Thomas' PET Centre, London UK; Department of Cancer Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, London UK.

European Journal of Radiology
|May 16, 2019
PubMed
Abstract

Insights

18F-FDG PET/MRI shows promise for staging malignant pleural mesothelioma (MPM), offering potentially more accurate loco-regional staging compared to PET/CT. This imaging technique demonstrated higher concordance with pathological staging, especially for T staging in MPM patients.

Area of Science:

  • Oncology
  • Radiology
  • Nuclear Medicine

Background:

  • Malignant pleural mesothelioma (MPM) staging is crucial for treatment planning.
  • Accurate loco-regional staging is essential for determining the optimal therapeutic strategy in MPM.
  • Current staging methods have limitations in precisely assessing the extent of disease.

Purpose of the Study:

  • To evaluate the performance of 18F-FDG PET/MRI in the loco-regional staging of MPM.
  • To compare the accuracy of 18F-FDG PET/MRI with 18F-FDG PET/CT and pathological staging.
  • To assess inter-observer agreement for MPM staging using 18F-FDG PET/MRI.

Main Methods:

  • Prospective study of consecutive MPM patients undergoing pre-operative staging with 18F-FDG PET/CT and same-day integrated 18F-FDG PET/MRI.
  • Clinical TNM staging performed by two independent readers on 18F-FDG PET/MRI.
  • Comparison of 18F-FDG PET/MRI and 18F-FDG PET/CT staging with final pathological stage.

Main Results:

  • 18F-FDG PET/MRI showed 67% concordance with pathological staging, compared to 33% for 18F-FDG PET/CT.
  • T staging concordance was 78% for 18F-FDG PET/MRI versus 33% for 18F-FDG PET/CT.
  • N staging concordance was 78% for both modalities. Good inter-observer agreement was noted for overall PET/MRI staging.

Conclusions:

  • 18F-FDG PET/MRI is a feasible technique for clinical staging of MPM.
  • 18F-FDG PET/MRI potentially offers more accurate loco-regional staging than 18F-FDG PET/CT, particularly for T staging.
  • Further studies are warranted to confirm the role of 18F-FDG PET/MRI in MPM management.
Keywords:
Fluorodeoxyglucose F18Magnetic resonance imagingMesotheliomaNeoplasmPositron emission tomography computed tomographyStaging

More Related Videos

Visualization and Quantification of Brown and Beige Adipose Tissues in Mice using [18F]FDG Micro-PET/MR Imaging08:31

Visualization and Quantification of Brown and Beige Adipose Tissues in Mice using [18F]FDG Micro-PET/MR Imaging

Published on: July 1, 2021

3.5K
Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines08:01

Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines

Published on: April 21, 2022

2.2K

Related Concept Videos

Pleural Effusion I: Introduction01:25

Pleural Effusion I: Introduction

Pleural effusion is an abnormal fluid accumulation in the pleural cavity, a narrow space between the lungs and the chest wall. It is not a disease per se but rather a symptom or indication of an underlying disease. In normal circumstances, this space contains a small amount of fluid (5 to 15 mL), a lubricant facilitating the non-frictional movement of the pleural surfaces.
There are two main types of pleural effusion: transudative and exudative. They are differentiated using Light's...
4.1K
Pleural Disorders: Types and Brief Description01:30

Pleural Disorders: Types and Brief Description

The pleura is a vital part of the respiratory system. It's a double-layered membrane surrounding the lungs and lining the chest cavity. The two layers of the pleura are:
641
Pleural Effusion II: Symptoms and Management01:28

Pleural Effusion II: Symptoms and Management

Pleural Effusion Overview
A pleural effusion is the abnormal collection of fluid between the parietal and visceral pleura layers of tissue that form the lining of the lungs and chest cavity. It can occur independently or due to surrounding parenchymal diseases, such as infection, malignancy, or inflammatory conditions.
Clinical Manifestations:
701
IR Frequency Region: Fingerprint Region01:03

IR Frequency Region: Fingerprint Region

IR spectra are divided into two main regions: the diagnostic region and the fingerprint region. The diagnostic region of the spectrum lies above 1500 cm−1. The absorptions resulting from single-bond vibrations of the N–H, C–H, and O–H stretch at higher wavenumbers and appear on the left side of the spectrum. The stretching absorptions of the C≡C and C≡N occur between 2100–2300 cm−1. In contrast, those arising from stretching absorptions of the...
1.9K
The Eukaryotic Promoter Region02:40

The Eukaryotic Promoter Region

The eukaryotic promoter region is a segment of DNA located upstream of a gene. It contains an RNA polymerase binding site, a transcription start site, and several cis-regulatory sequences.  The proximal promoter region is located in the vicinity of the gene and has cis-regulatory sequences and the core promoter. The core promoter is the binding site for RNA polymerase and is usually located between -35 and +35 nucleotides from the transcription start site. The distal promoter regions are...
18.7K
Region of Convergence01:17

Region of Convergence

The z-transform is a powerful mathematical tool used in the analysis of discrete-time signals and systems. It is a crucial tool in the analysis of discrete-time systems, but its convergence is limited to specific values of the complex variable z. This range of values, known as the Region of Convergence (ROC), is fundamental in determining the behavior and stability of a system or signal. The ROC defines the region in the complex plane where the z-transform converges, which can take various...
909