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Lung Capacity01:47

Lung Capacity

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Tissue Transplantation01:24

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Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
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Related Experiment Video

Updated: Jan 25, 2026

Author Spotlight: Recent Advancements in Reoperative Foregut Surgery
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Author Spotlight: Recent Advancements in Reoperative Foregut Surgery

Published on: September 22, 2023

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Foregut function before and after lung transplant.

Takahiro Masuda1, Sumeet K Mittal1, Balázs Kovács2

  • 1Norton Thoracic Institute, St Joseph's Hospital and Medical Center, Phoenix, Ariz; Creighton University School of Medicine-Phoenix Regional Campus, Phoenix, Ariz.

The Journal of Thoracic and Cardiovascular Surgery
|May 16, 2019
PubMed
Summary
This summary is machine-generated.

Lung transplant improves esophageal function, increasing peristaltic vigor and reducing reflux in patients with advanced lung disease. This restoration of pulmonary physiology aids foregut function post-transplant.

Keywords:
gastroesophageal reflux diseasehigh-resolution manometrylung transplantobstructive lung diseaserestrictive lung disease

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Area of Science:

  • Gastroenterology
  • Pulmonology
  • Transplant Surgery

Background:

  • Esophageal dysmotility and GERD are common in advanced lung disease.
  • Their impact on lung transplant outcomes is unclear.
  • Effects of lung transplant on foregut function are unknown.

Purpose of the Study:

  • Assess foregut function before and after bilateral lung transplant.
  • Compare obstructive vs. restrictive lung disease patients.
  • Evaluate changes in esophageal motility and reflux.

Main Methods:

  • Complete foregut function testing pre- and post-lung transplant.
  • Comparison of obstructive and restrictive lung disease cohorts.
  • Lung transplant procedures performed between 2015-2016.

Main Results:

  • 112 patients included; mean age 62.2 years, 62% male.
  • Half experienced manometric changes post-transplant, mostly improved vigor.
  • Pre-transplant GERD and higher thoracoabdominal pressure gradient seen in restrictive lung disease.

Conclusions:

  • Esophageal motility and reflux differ between obstructive and restrictive lung disease.
  • Lung transplant improves esophageal dysmotility and reflux by restoring pulmonary physiology.
  • Improved peristaltic vigor post-transplant may impact eligibility for antireflux surgery.