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Upper limb motor training based on task-oriented exercises induces functional brain reorganization in patients with
Laura Bonzano1, Ludovico Pedullà2, Andrea Tacchino3
1Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Genoa, Italy.
Neuroscience
|May 16, 2019
Summary
Active upper limb training improved motor skills and brain function in multiple sclerosis patients. Voluntary movements led to more typical brain activation patterns, suggesting better skill acquisition.
Area of Science:
- Neurorehabilitation
- Neuroplasticity
- Motor Control
Background:
- Multiple sclerosis (MS) often causes upper limb sensorimotor deficits.
- Understanding the impact of rehabilitation on brain activity in MS is crucial.
Purpose of the Study:
- To investigate changes in motor performance and brain activation after upper limb motor training in individuals with MS.
- To compare the effects of voluntary task-oriented movements versus passive mobilization.
Main Methods:
- Thirty MS patients with mild deficits were randomized into an active (voluntary movements) or passive (mobilization) group.
- Intervention lasted 8 weeks, with 3 sessions/week.
- Motor performance assessed using ARAT, NHPT, and grip strength.
- Brain activation patterns measured using functional magnetic resonance imaging (fMRI) during finger movements.
Main Results:
- Both active and passive interventions improved motor performance (NHPT, grip strength, ARAT trends).
- Only the active group showed increased lateralization of brain activation towards a more typical pattern (left hemisphere, right cerebellum).
- Active training potentially reflects skill acquisition, reducing compensatory brain resource demand.
Conclusions:
- Both active and passive interventions enhance motor function in MS.
- Voluntary, task-oriented training induces neuroplastic changes, optimizing brain resource utilization for motor tasks.
Keywords:
fMRIhemispheric lateralizationmultiple sclerosisupper limb motor trainingvoluntary movementsMore Related Videos
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